元胡止痛胶囊中重金属、有害元素的测定  

Determination of heavy metals and harmful elements in Yuanhu zhitong capsule

作　　者：冯凯[1,2] 房庆圆[3] 吕峰 聂磊[1] 

机构地区：[1]山东大学药学院,山东济南250012 [2]济宁市食品药品检验检测中心,山东济宁272100 [3]山东理工职业学院,山东济宁272067

出　　处：《中国生化药物杂志》2016年第4期182-185,共4页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的为了解市售元胡止痛胶囊中重金属及有害元素的含量。方法采用原子吸收分光光度法和原子荧光光谱法,建立铅、镉、砷、汞、铜及铬等的含量测定方法。结果建立的方法回收率在91.2%-111.2%之间,精密度实验RSD均小于5%,各元素测定范围内线性关系良好。该测定方法稳定性和重复性良好。元胡止痛胶囊中铅、镉、铜含量有不同程度超标,砷、汞、铬含量符合要求。结论该方法简单易行,方便快捷。现行的元胡止痛胶囊质量标准还需建立铅、镉、砷、汞、铜及铬的含量限度。本方法所建立的重金属及有害元素测定方法为元胡止痛胶囊的质量控制及安全性评价提供参考。Objective To determine the content of heavy metals and harmful elements in commercially available Yuanhu Zhitong Capsule.Methods The determination of lead,cadmium,arsenic,mercury,copper and chromium by atomic absorption spectrometry and atomic fluorescence spectrometry was established. Results The recovery rate of the method was between 91. 2% and 111. 2%,and the precision of the experiment was less than 5%,and the range of each element was good. The stability and reproducibility of the method were good. Lead and cadmium and copper of Yuanhu zhitong capsule in different degree exceeded the standard,while the content of arsenic,mercury and chromium was in accordance with the requirements.Conclusion The method is simple and easy to operate,convenient and quick. The content of the current limit of Yuanhu zhitong capsule still need to establish the quality standard of lead and cadmium,arsenic,mercury,copper and chromium. In this paper,the establishment of the heavy metals and harmful elements determination method of Yuanhu zhitong capsule provide quality control and safety evaluation of reference.

关 键 词：元胡止痛胶囊 重金属 有害元素 原子吸收分光光度法 原子荧光光谱法 

分 类 号：R917[医药卫生—药物分析学]