中药对脾胃积热型过敏性紫癜免疫功能的影响  

Chinese Herbs for Children with Henoch-Schonlein Purpura Caused by Spleen Accumulated Heat the Influence of Immune Function

作　　者：杨昆[1] 李叶雨[2] 王飞[2] 卢野[2] 陈燕子[2] 杜红霞[2] 黎欣[1] 

机构地区：[1]成都中医药大学附属医院,四川成都610072 [2]成都中医药大学,四川成都610075

出　　处：《成都中医药大学学报》2016年第2期52-54,94,共4页Journal of Chengdu University of Traditional Chinese Medicine

基　　金：四川省专业技术人才队伍建设专项基金(编号:CRS2014002)

摘　　要：目的：探讨中药免煎颗粒加味泻黄散对脾胃积热所致儿童过敏性紫癜（HSP）的治疗效果及免疫功能的影响。方法：将我院2014年6月~2016年1月初诊的脾胃积热型HSP患儿120例,通过数字随机法分成2组,西医治疗组和中西医结合治疗组,分别在治疗前后应用ELISA方法测定外周血IL-10、IL-12水平,并随访6个月。结果：治疗前西医治疗组、中西医结合治疗组IL-10、IL-12低于正常对照组（P〈0.05）有统计学意义。治疗2 w后,2组IL-10、IL-12水平明显升高,与正常对照组比较（P〉0.05）无统计学意义。中西医结合治疗组总有效率95.00﹪与西医治疗组总有效率86.67﹪比较（P〈0.05）有统计学意义;随访6个月,中西医结合治疗组复发率3.51%与西医治疗组复发率11.54%比较（P〈0.05）有统计学意义。结论：加味泻黄散对儿童脾胃积热型过敏性紫癜早期治疗效果明显,同时可有效减少复发率,其疗效机制与免疫调控相关。Objective： To study the effect treatment for Children with spleen and stomach heat type of HSP through herbal concentrate-granules of flavored xiehuang powder and its immune adjustment mechanism. Methods： To collect taste product heat caused by HSP 120 cases of patients from 2014. 6 ~ 2016. 1 in Affiliated Hospital of Chengdu University of TCM.,digital randomly divided into two groups of type 2,western medicine treatment group and combine traditional Chinese with western medicine treatment group,determination of peripheral blood before and after the treatment 2 weeks of IL-10,IL-12 levels,and 6 months follow-up. Results： Before treatment,the levels of IL- 10,IL- 12 of the western medicine group and combine traditional Chinese with western medicine group were lower than that of normal control group,（ P ﹤ 0. 05） was statistically significant. Two weeks after the treatment,two groups of IL-10,IL-12 levels compared with normal control group（ P〉0. 05） had no statistical significance. Combine traditional Chinese with western medicine group total effective rate of 95. 00%,western medicine group total effective rate of 86. 67%,the comparison（ P ﹤ 0. 05） was statistically significant; and after six months of period,combine traditional Chinese with western medicine group recurrence rate was 3. 51%,the western medicine group recurrence rate was 11. 54%,the comparison（ P ﹤ 0. 05） was statistically significant. Conclusion： Flavored xiehuang powder combined with western medicine treatment of spleen and stomach heat caused by HSP can be effective,reduce the recurrence rate,and the curative effect mechanism related to immune function regulation.

关 键 词：过敏性紫癜 加味泻黄散 脾胃积热 免疫调控 

分 类 号：R28[医药卫生—中药学] R554[医药卫生—中医学]