乙酸抗细菌生物膜作用的研究进展  

Advances in the progress of anti-bacterial biofilms properties of acetic acid

作　　者：高欣欣[1] 金正花[1] 陈欣欣[1] 于家傲[1] 

机构地区：[1]吉林大学第一医院烧伤外科,长春130061

出　　处：《中华烧伤杂志》2016年第6期382-384,共3页Chinese Journal of Burns

摘　　要：细菌生物膜因其独特的组织结构，而对抗生素及其他抗菌物质有极强的耐药性。美国疾病控制中心相关数据表明，65%～80%的人类细菌感染与细菌生物膜有关，50%的院内感染与医疗器械装置上的细菌生物膜有关。细菌生物膜已经成为慢性感染迁延不愈，手术及局部给药治疗效果不佳的主要原因之一。乙酸作为抗菌剂及防治瘟疫的药物已有6 000多年的历史 。最新实验表明，乙酸具有确切的抑制及清除细菌生物膜的作用，但因其作用机制及毒性和不良反应尚未明确，无法在临床得到广泛应用。本文旨在通过概述细菌生物膜的特点、主要治疗方法及乙酸抗细菌生物膜作用的研究进展，进一步明确乙酸在慢性感染治疗中的重要意义。Bacterial biofilms are considered to be the hindrance in the treatment of chronic wound, because of their tolerance toward antibiotics and other antimierohia] agents. They also have strong ability to escape from the host immune attack. Acetic acid, as a kind of organic weak acid, can disturb the bio- films by freely diffusing through the bacterial biofilms and bacterial cell membrane structure. Then the acid dissociates to release the hydrogen ions, leading to the disorder of the acid-base im- balance, change of protein conformation, and the degradation of the DNA within the membranes. This paper reviews the litera- ture on the characteristics and treatment strategies of the bacterial biofilms and the acetic acid intervention on them, so as to demonstrate the roles acetic acid may play in the treatment of chronic wound, and thus provide a convincing treatment strategy for this kind of disease.

关 键 词：生物膜 感染 醋酸 慢性创面 

分 类 号：R318.08[医药卫生—生物医学工程]