格列喹酮胶囊体外溶出速率的实验  

Studies of the Dissolution Rate of Piroxicam in Gliquidone Capsules

作　　者：吴钢伟[1] 

机构地区：[1]福建省立医院药学部,福州350001

出　　处：《海峡药学》2016年第4期72-74,共3页Strait Pharmaceutical Journal

摘　　要：目的研究格列喹酮胶囊体外溶出速率的方法。方法溶出度与释放度测定法中国药典(通则0931第二法)以磷酸盐缓冲液(取磷酸二氢铵35.6g,加水500m L溶解后,用30%枸橼酸调节p H7.5)为溶出介质,格列喹酮胶囊的溶出量采用高效液相色谱法测定。结果格列喹酮胶囊浓度在50~500μg·m L^(-1)范围内与各自的峰面积呈良好的线性关系,r为0.9998。平均回收率为99.7%,RSD0.5%。该样品45min溶出量就在75%以上。结论本方法用于格列喹酮胶囊中格列喹酮的溶出度测定切实可行。OBJECTIVE To study the dissolution rate in vitro of Piroxicam in Gliquidone Capsules. METHODS Method was used as the stirring element. solvent was phosphate puffer. The dissolution rate of its entecavir was determined by HPLC. RESULTS The calibration curves were linear in the range of 50-500μg · m L- 1,r =0. 9998. The average recoveries were 99. 7% with RSD was 0. 7%. The average dissolution of entecavir for this drug exceeded the marker amount by75% in 45 minutes. CONCLUSION The method is good for the dissolution determination of Piroxicam in Piroxicam tablets.

关 键 词：格列喹酮 格列喹酮胶囊 溶出度 

分 类 号：R927.11[医药卫生—药学]