ACEⅠ/D基因多态性与儿童原发性肾病综合征的相关性分析  

Association of ACEⅠ/D Gene Polymorphism with Primary Nephritic Syndrome in Children

作　　者：于海绍 魏青[2] 张磊[1] 覃远汉[1] 龚玲[1] 宋坤岭 

机构地区：[1]广西医科大学第一附属医院,南宁530021 [2]广西医科大学,南宁530021

出　　处：《基因组学与应用生物学》2016年第5期1020-1023,共4页Genomics and Applied Biology

摘　　要：为探讨血管紧张素Ⅰ转化酶(ACE)基因插入/缺失(Ⅰ/D)多态性与儿童原发性肾病综合征(PNS)的相关性。我们选取PNS组患儿103例,其中激素敏感组54例,激素耐药组49例,正常组为健康儿童114例,采用聚合酶链反应技术(PCR)分析ACE基因Ⅰ/D多态性与在各组中的分布,并进行统计学分析。结果显示PNS组与正常组ACEⅠ/D基因型及等位基因频率分布比较差异无统计学意义,激素敏感组与激素耐药组ACEⅠ/D基因型及等位基因频率分布比较差异也无统计学意义。本研究表明ACEⅠ/D基因多态性与PNS的发生无明确关联;ACEⅠ/D基因多态性与激素治疗效应也无明确关联。To investigate the associations between the ACEⅠ/D gene polymorphism and primary nephritic syndrome（PNS） in children. We studied 103 children with PNS（54 with glucocorticoid-sensitive, 49 with glucocorticoid-resistant） and 114 healthy controls to analyse the distribution of the polymorphism in the two groups by PCR.No significant difference either in genotypic or allelic frequencies of ACEⅠ/D gene polymorphism were observed between PNS patients and controls（p〈0.05）. Allele frequency and genotype distribution also showed no significant difference between the glucocorticoid-sensitive group and the glucocorticoid-resistant group（p〈0.05）. There was no clear association between ACEⅠ/D gene polymorphism and the risk for PNS in children. ACEⅠ/D gene polymorphism might not be associated with glucocorticoid treatment response in children with PNS.

关 键 词：儿童 原发性肾病综合征 基因多态性 血管紧张素Ⅰ转化酶 

分 类 号：R726.9[医药卫生—儿科]