维持性血透患者特殊人群消化道肿瘤标志物参考值的建立  

Reference range determination for gastrointestinal tumor markers in patients on maintenance dialysis

作　　者：赵洪刚[1] 焦妍[1] 张遵城[1] 

机构地区：[1]天津医科大学第二医院核医学科,天津市300211

出　　处：《世界华人消化杂志》2016年第15期2429-2433,共5页World Chinese Journal of Digestology

摘　　要：目的:确定维持性血液透析透患者癌胚抗原(carcinoembryonic antigen,CEA)、甲胎蛋白(α-fetoprotein,AFP)、糖类抗原199(carbohydrate antigen 199,CA199)、C A72-4等消化系相关肿瘤标志物的特殊人群参考值范围.方法:选择天津医科大学第二医院2014-01/2016-02血液净化科维持性血液透析6 mo以上的终末期肾病患者共397例,其中男203例,女194例,健康查体者272例,男139例,女133例,采用化学发光法检测CEA、AFP、CA199,采用电化学发光法检测CA72-4,建立维持性血液透析患者消化道肿瘤标志物的特殊人群参考值.结果:维持性透析患者肿瘤标志物CEA、CA199、CA72-4检测值和阳性率均高于正常对照组.AFP的检测值和正常人群无统计学差异.维持性血液透析患者95分位检测值分别为:CEA8.1 ng/mL、CA199 135.8 U/mL、CA72-4 11.2 ng/mL.结论:维持性血透患者特殊人群消化道肿瘤标志物参考范围如下:CEA≤8.1 ng/m L,CA199≤135.8 U/mL、CA72-4≤11.2 ng/mL,均高于正常人群参考值范围.AIM：To identify the reference range of carcinoembryonic antigen（CEA）,α-fetoprotein（AFP）,carbohydrate antigen 199（CA199） and carbohydrate antigen 72-4（CA72-4） in patients on maintenance hemodialysis.METHODS：A total of 397 patients（203males and 194 females） on maintenance hemodialysis were recruited at the Second Hospital of Tianjin Medical University between January 2014 and February 2016.Meanwhile,272 healthy adult volunteers（139males and 133 females） were included in a control group.Serum levels of CEA,CA199 and AFP were detected by chemiluminescence assay.Serum level of CA72-4 was detected by electrochemiluminescence assay.The reference ranges of CEA,CA199,AFP and CA72-4 were evaluated by Wilcoxon Mann-Whitney test and Chi-squared test.RESULTS：Serum levels of CEA,CA199 and CA72-4 in patients on maintenance hemodialysis were significantly higher than those in the healthy control group（P 〈0.05）.Positive rates of the above three markers were also higher in patients on maintenance hemodialysis compared to the normal control group.Serum AFP levels did not differ significantly between patients on maintenance hemodialysis and the control group.The 95 th percentile for CEA,CA199 and CA72-4 was identified to be 8.1 ng/mL,135.8 U/mL and 11.2ng/mL,respectively.CONCLUSION：We identified the 95 th percentile values of CEA,CA199 and CA72-4in patients on maintenance hemodialysis,which were higher than those of the control group.

关 键 词：维持性血液透析 甲胎蛋白 糖类抗原199 糖类抗原72-4 

分 类 号：R692[医药卫生—泌尿科学] R730.43[医药卫生—外科学]