5-氟尿嘧啶治疗药物监测的研究现状  

Research status of therapeutic drug monitoring of 5-fluorouracil

作　　者：时静 陈海生[1] 段存贤 史文娜[1] 李辉[1] 李慧 刘玉国[1] 

机构地区：[1]山东省肿瘤防治研究院药学部,济南250117

出　　处：《中国临床药理学杂志》2016年第11期1053-1056,共4页The Chinese Journal of Clinical Pharmacology

基　　金：山东省医学科学院院级科技计划基金资助项目(2014-64)

摘　　要：5-氟尿嘧啶(5-FU)的治疗窗窄且个体间药代动力学差异巨大,直接影响到药物的疗效和不良反应。通过治疗药物监测(TDM)进行5-FU的剂量调节,可以提高临床疗效、降低不良反应发生率。本文就5-FU TDM的研究进展作一综述,以促进5-FU的临床合理使用。5-fluorouracil is generally characterized by a narrow therapeutic index and a large interindividual pharmacokinetics variability that has a direct effect on adverse drug reactions and efficacy. To optimize the dose of 5-FU based on therapeutic drug monitoring（ TDM） has been shown to result in a significantly improved efficacy and reduced the incidence of adverse drug reaction. We review the data on TDM of 5-FU in order to promote the clinical application.

关 键 词：5-氟尿嘧啶 治疗药物监测 剂量调整 药代动力学 

分 类 号：R979.1[医药卫生—药品]