逐步回归分析法研究影响山楂叶混合粉压缩成型性的粉体学性质  

Effects of Key Micromeritic Properties on Compactibility of Crataegi Folium Blended Powder by Stepwise Regression Analysis

作　　者：罗娟[1] 蒋且英[1] 廖正根[1] 李哲[1,2] 曾荣贵 吕丹[1] 梁新丽[1] 孔小强 

机构地区：[1]江西中医药大学现代中药制剂教育部重点实验室,继续教育学院,南昌330004 [2]郑州市妇幼保健院,郑州450012

出　　处：《中国实验方剂学杂志》2016年第12期7-12,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81160522);“赣鄱555”工程领军人才培养项目

摘　　要：目的:研究山楂叶混合粉的粉体学性质对其压缩成型性的影响。方法:以山楂叶50%乙醇提取的浸膏粉为模型药物,采用3种制备工艺,分别与2种辅料(微晶纤维素、可溶性淀粉)按质量比1∶0.5,1∶1,1∶2混合制备混合粉体,得18种山楂叶混合粉体。以抗张强度-压力回归方程中斜率为指标评价山楂叶混合粉的压缩成型性,运用逐步回归分析法研究山楂叶混合粉压缩成型性与粉体学性质之间的相关性。结果:山楂叶混合粉压缩成型性与粉体的振实密度(ρ_t),累计孔体积(PV),含水量(MC)及临界相对湿度(CRH)呈正相关,与粉体的50%通过粒径(D50),粒径距(Span),松散密度(ρ_b),Carr指数(CI),豪斯纳比率(HR)及比表面积(SSA)呈负相关。结论:ρ_b,ρ_t,Span,MC和CRH是影响山楂叶混合粉压缩成型性的关键粉体学性质。Objective： To establish a relationship between micromeritic properties of Crataegi Folium blended powder and its compactibility. Method： Taking 50% ethanol extract powder of Crataegi Folium as a model drug,blended powder of Crataegi Folium were obtained by three kinds of drying technology and mixed with microcrystalline cellulose（ MCC） and soluble starch at mass ratio of 1 ∶ 0. 5,1 ∶ 1 and 1 ∶ 2,respectively. The compactibility of blended powder was evaluated by monitoring the slope k in regression equation of tensile strengthpressure. Effect of micromeritic properties on compactibility was analyzed by stepwise regression analysis. Result：It was suggested from data of stepwise regression that compactibility was positively correlated to tap density（ ρ_t）,cumulative pore volume（ P_V）,moisture content（ MC） and critical relative humidity（ CRH）,and negatively correlated with D50,particle distance（ Span）,bulk density（ ρ_b）,Carr index（ CI）,Hausner ratio（ HR）,specific surface area（ SSA）. Conclusion： Span, ρb,ρt,MC and CRH are proved as the key micromeritic properties involving in compactibility of Crataegi Folium blended powder.

关 键 词：山楂叶 混合粉 粉体学性质 压缩成型性 抗张强度 逐步回归分析 

分 类 号：R283.6[医药卫生—中药学] R284.2[医药卫生—中医学]