Zirconium-mediated Selective Synthesis of 1,4-Dialkyl（aryl）-hexa-substituted Benzenes from Two Silyl-substituted Alkynes and One Internal Alkyne  

作　　者：LI Junqiu ZHANG Jiqian QU Hongmei LIU Jun LI Juan ZHOU Lishan 

机构地区：[1]Key Laboratory of Systems Bioengineering, Ministry of Education, Department of Pharmaceutical Engineering School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China [2]Nantong Dongchang Chemical Industrial Co., Ltd., Nantong 226407, P. R. China [3]CNOOC Tianjin Chemical Research and Design Institute, Tianjin 300131, P. R. China

出　　处：《Chemical Research in Chinese Universities》2016年第3期366-372,共7页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China（No.21102099）.

摘　　要：Based on the formation of 2,5-bis（trimethylsilyl）-zirconacyclopentadienes from two silylalkynes with CpEZrBu2 and the Cu-mediated formation of 1,4-disilylbenzene via the cycloaddition of zirconacyclopentadienes to disubstituted alkynes, a selective synthesis of 1,4-dialkyl（aryl）-hexa-substituted benzenes was achieved followed by iodination and coupling reaction. The coupling reactions were carried out with either organolithium reagent or orga- nozinc reagent（Negishi coupling）, depending on the electrophilic species.Based on the formation of 2,5-bis（trimethylsilyl）-zirconacyclopentadienes from two silylalkynes with CpEZrBu2 and the Cu-mediated formation of 1,4-disilylbenzene via the cycloaddition of zirconacyclopentadienes to disubstituted alkynes, a selective synthesis of 1,4-dialkyl（aryl）-hexa-substituted benzenes was achieved followed by iodination and coupling reaction. The coupling reactions were carried out with either organolithium reagent or orga- nozinc reagent（Negishi coupling）, depending on the electrophilic species.

关 键 词：ZIRCONIUM Hexa-substituted benzene IODINATION Coupling reaction 

分 类 号：O625.11[理学—有机化学] TQ925[理学—化学]