NFKB1基因启动子区-94ins/del ATTG多态性与冠心病关联性的荟萃分析  

Meta-analysis of association between-94 ins/del ATTG polymorphism in the promoter region of NFKB1 gene and coronary heart disease

作　　者：刘倩[1] 刘欣跃[1] 李林静[1] 李婧[1] 张尚弟[1] 潘云燕[1] 刘泽菁[1] 王君[1] 

机构地区：[1]兰州大学第二医院检验医学中心,兰州730030

出　　处：《临床检验杂志》2016年第3期225-228,共4页Chinese Journal of Clinical Laboratory Science

基　　金：甘肃省自然科学基金(1506RJYA243)

摘　　要：目的探讨NFKB1基因启动子区-94ins/del ATTG多态性与冠心病（CHD）的关联性。方法计算机检索Pub Med、CNKI、万方等数据库,获取有关NFKB1基因启动子区-94 ins/del ATTG多态性与CHD关联性的病例-对照研究,用Stata 11.0软件在等位基因、纯合子、显性和隐性基因模型下进行荟萃（meta）分析。根据异质性检验结果选择固定或随机效应模型进行数据合并,并采用Begg＇s漏斗图和Egger＇s检验评价发表偏倚。结果共纳入8篇文献,研究对象共14 649例;Meta分析结果显示,携带D等位基因的人群,CHD易感性增加（OR=1.28,95%CI=1.22～1.35,POR〈0.01）;基因型为DD的人群发病风险高于II基因型（OR=1.32,95%CI=1.19～1.47,POR〈0.01）;显性模型中DD＋ID基因型的人群发病风险高于II基因型的人群（OR=1.15,95%CI=1.07～1.24,POR〈0.01）;隐性模型中DD基因型的人群发病风险高于ID＋II基因型（OR=1.26,95%CI=1.15～1.38,POR=0.002）。亚组分析结果显示,NFKB1基因启动子区-94ins/del ATTG多态性与CHD易感性在亚洲及欧洲人群中有关联,而在北美洲人群中并未表现出这种相关性。结论 NFKB1基因启动子区-94ins/del ATTG多态性与CHD的易感性显著相关,但主要表现在亚洲和欧洲人群。Objective To investigate the association between-94 ins / del ATTG polymorphism in the promoter region of NFKB1 gene and coronary heart disease（ CHD）. Methods The case-control studies for the association between-94 ins / del ATTG polymorphism in the promoter region of NFKB1 gene and CHD were searched from the databases of Pub Med,CNKI and Wanfang. Then,the meta-analysis of the allele,homozygous,dominant and recessive genetic model was performed using Stata 11. 0 software. Fixed or random effect model was chosen to merge the data according to heterogeneity inspection results,and the publication bias was evaluated by the Begg＇s funnel plot and Egger＇s test. Results A total of 8 studies were included,and 14 649 subjects were contained. The meta-analysis results showed that the susceptibility to CHD in the subjects carried D allele increased（ OR = 1. 28,95% CI = 1. 22-1. 35,POR 0. 01）,the risk of CHD in the subjects with DD genotype was significantly higher than that with II genotype（ OR = 1. 32,95% CI = 1. 19-1. 47,POR 0. 01）,the risk of CHD in the subjects with DD ＋ ID genotype was significantly higher than that with II genotype（ OR =1. 15,95% CI = 1. 07-1. 24,POR 0. 01）,and that the risk of CHD in the subjects with DD genotype was significantly higher than that with ID ＋ II genotype（ OR = 1. 26,95% CI = 1. 15-1. 38,POR= 0. 002）. The subgroup analysis results showed that the-94 ins / del ATTG polymorphism in the promoter region of NFKB1 gene was correlated with CHD in the population of Asia and Europe,but not in North America. Conclusion The-94 ins / del ATTG polymorphism in the promoter region of NFKB1 gene is obviously correlated with CHD,but mainly in the population of Asia and Europe.

关 键 词：NFKB1 冠心病 单核苷酸多态性 荟萃分析 

分 类 号：R541.4[医药卫生—心血管疾病]