糖尿病视网膜病变发病机制研究进展  

Recent advances in pathological mechanisms of diabetic retinopathy

作　　者：张凤俊[1] 易敬林[1] 李晶明[1] 刘秋平[1] 

机构地区：[1]南昌大学附属眼科医院,江西省眼科学和视觉科学研究所,江西省南昌市330006

出　　处：《眼科新进展》2016年第6期584-587,共4页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助(编号:81400427;81460163;81300786);高等学校博士学科点专项科研基金(编号:20133601120012);江西省科技厅科技项目(编号:20142BAB215029;20132BAB205024;20142BDH80005);江西省教育厅科技项目(编号:GJJ14094;GJJ13175)~~

摘　　要：糖尿病视网膜病变(diabetic retinopathy,DR)是糖尿病微血管并发症的眼部表现,是全球成人不可逆性盲的主要原因之一。尽管国内外有关DR代谢途径的分子机制研究很多,但迄今为止仍然无法对其给予有效地预防和治疗。目前已发现多条与DR发病机制相关的细胞内信号转导途径,并具有交互作用。寻找调控信号通路中起阀门作用的分子开关,可有效地阻止DR病理代谢途径的发展,为临床上治疗DR提供新的思路。本文针对DR发病机制及参与其中的信号通路进行综述。Diabetic retinopathy（DR）,a chronic and multifactorial ocular microvascular complication of diabetes,is the leading cause of blindness in working age population.Although there are many researches about the pathologic mechanisms of DR,it remains hard to be prevented and treated.The pathogenesis of diseases is the result of waterfall cascades,which is involved with multiple signaling pathways.It has been found that a lot of intracellular signal transduction pathways with cross-talking are related to DR.Controlling the molecular switch in signaling pathways could not only prevent the progress of the disease effectively,but also provide a new idea for the clinic therapy of DR.This article reviews the pathogenesis of DR and its relevant signal pathways.

关 键 词：糖尿病视网膜病变 发病机制 信号通路 

分 类 号：R587.2[医药卫生—内分泌]