如意珍宝片对血管性痴呆模型大鼠的保护作用  

Protective effects of Ruyi Zhenbao Tablet on vascular dementia in rats

作　　者：陈维武 景小龙[2] 刘静[2] 田兴美[2] 申秀萍[2] 

机构地区：[1]西藏奇正藏药股份有限公司,北京100000 [2]天津药物研究院新药评价有限公司,天津300301

出　　处：《药物评价研究》2016年第2期220-223,共4页Drug Evaluation Research

摘　　要：目的研究如意珍宝片对血管性痴呆(VD)大鼠的保护作用。方法采用改良双侧颈总动脉永久性结扎法制备大鼠VD模型,以Y迷宫为学习记忆评价指标,并测定VD大鼠脑内多巴胺(DA)、去甲肾上腺素(NE)、5-羟色胺(5-HT)3种单胺类神经递质水平。结果如意珍宝片能显著的增加Y迷宫的正确次数和提高脑内3种单胺类神经递质水平。结论如意珍宝片能提高VD大鼠学习记忆能力,升高脑内单胺类神经递质水平,从而改善大脑皮层的兴奋性,激活脑损伤后的学习记忆过程。Objective To investigate the protective effects ofRuyi Zhenbao Tablet （RZT） on vascular dementia in rats. Methods The permanent bilateral common carotid artery ligation method was used to establish the rat model of vascular dementia （VD）. The learning and memory abilities were evaluated by Y maze. Besides, the levels of three monoamine neurotransmitters including dopamine （DA）, norepinephrine （NE）, and 5-hydroxytryptamine （5-HT） within rat brain were also determined. Results The correct number of Y maze and the brain levels of three monoamine neurotransmitters can be significantly enhanced in the VD models treated by RZT compared to other controls. Conclusion RZT was able to enhance the learning and memory abilities of VD rats and protect the monoamine neurotransmitters, as a result the cerebral cortex excitability of the VD rats was improved and thereafter, the learning and memory procedure was exited in the rats with brain injury.

关 键 词：如意珍宝片 血管性痴呆 单胺类神经递质 学习记忆 Y迷宫 

分 类 号：R965[医药卫生—药理学]