虎杖的化学成分及药理作用研究进展  

Research progress on chemical constituents in roots and rhizomes of Polygonum cuspidatum and their pharmacological activities

作　　者：时圣明[1] 潘明佳[1] 王文倩[1] 王洁[1] 陈常青[1] 

机构地区：[1]天津药物研究院,天津300193

出　　处：《药物评价研究》2016年第2期313-317,共5页Drug Evaluation Research

基　　金：国家自然科学基金(2711001002001)

摘　　要：对近10年来中外期刊有关虎杖Polygonum cuspidatum的研究成果进行了检索,对从虎杖中分离并鉴定的化学成分及药理活性研究进展进行总结。虎杖中主要含有蒽醌类、二苯乙烯类、黄酮类、香豆素类以及一些脂肪酸类化合物,具有多种药理作用,包括抗炎、抗病毒、抗菌、调血脂、抗血栓、改变血流变、扩张血管、保护心肌、抗氧化、抗肿瘤,改善阿尔茨海默病及预防艾滋病等。多年来对虎杖的研究成果证明了其应用前景和开发价值,为更好地利用该资源提供依据。In recent 10 years, the lectures for studies on the roots and rhizomes ofPolygonum cuspidatum in both Chinese and foreign periodicals have been retrieved, the chemical constituents isolated and identified from the roots and rhizomes of P. cuspidatum and their pharmacological progress have been analyzed and summarized. There are main anthraquinones, stilbene, flavonoids, coumarins, and some fatty compounds in the roots and rhizomes of P. cuspidatum, which have a variety of pharmacological effects, including anti-inflammation, antivirus, antibiosis, regulation of blood lipid, antithrombosis, change of blood rheology, dilation of blood vessels, protection of myocardium, anti-oxidation, anticancer, improvement of Alzheimer＇s disease, prevention of AIDS, and so on. The studies on the roots and rhizomes ofP. cuspidatum over the years have proven its value and development prospects, and provide the information for the further development and utilization of the roots and rhizomes ofP. cuspidatum.

关 键 词：虎杖 蒽醌类 二苯乙烯类 黄酮类 香豆素类 抗炎 抗病毒 抗菌 调血脂 抗血栓 改变血流变 扩张血管 保护心肌 抗氧化 抗肿瘤 阿尔茨海默病 艾滋病 

分 类 号：R282.710.5[医药卫生—中药学]