多囊卵巢综合征患者的糖脂代谢特点分析  

Analysis on glycolipid metabolism features in patients with polycystic o-varian syndrome

作　　者：李霞[1] 彭璇[1] 段娟[1] 雷美云 

机构地区：[1]江西省九江市妇幼保健院辅助生殖科,江西九江332000

出　　处：《中国现代医生》2016年第12期17-21,共5页China Modern Doctor

基　　金：江西省卫生厅科技计划项目(20143264)

摘　　要：目的探讨多囊卵巢综合征（polycystic ovary syndrome,PCOS）患者生殖内分泌及糖脂代谢特点。方法选择2014年10月~2015年10月在我院就诊的PCOS患者48例,月经周期规律的输卵管因素不孕者36例作为对照组,经期抽血检测血清性激素、血糖、血脂水平,并分层分析两组肥胖与非肥胖者的糖脂代谢指标。分别比较两组糖、脂代谢指标及激素水平的差异。结果 PCOS组LH、AND、FAI、FIN、HOMA-IR、TG、TC、LDL-C水平显著高于对照组（P〈0.05）;SHBG、HDL-C显著低于对照组（P〈0.05）;其他指标差异无统计学意义（P〉0.05）。PCOS组肥胖者FAI、FIN、HOMA-IR、TG、TC、LDL-C显著高于非肥胖者（P〈0.05）;而SHBG、HDL-C显著低于非肥胖者（P〈0.05）;其他指标差异无统计学意义（P〉0.05）。对照组肥胖者与非肥胖者比较,FIN、HOMA-IR、TG、TC、LDL-C显著高于非肥胖者（P〈0.05）;SHBG、HDL-C显著低于非肥胖者（P〈0.05）;与PCOS组不同的是,FAI两者差异无统计学差异（P〉0.05）;其他指标差异无统计学意义（P〉0.05）。结论 PCOS患者具有糖脂代谢异常特征,肥胖是糖脂代谢异常的独立因素,减轻体重,预防心血管疾病值得关注。Objective To discuss the features of reproductive endocrinology and glycolipid metabolism in patients with polycystic ovarian syndrome（PCOS）.Methods 48 PCOS patients treated in our hospital from October 2014 to October2015 were selected,and another 36 infertile patients due to tubal factors with regular menstrual cycle were selected as control group.The levels of serum sex hormone,blood glucose,and blood lipid were tested during menstrual period,and the glycolipid metabolism indexes of obese and non-obese patients in two groups were stratified and analyzed.The differences of glycolipid metabolism indexes and levels of sex hormones were compared between two groups.Results The levels of LH,AND,FAI,FIN,HOMA-IR,TG,TC,and LDL-C were significantly lower in the PCOS group than in the control group（P〈0.05）.The other indexes showed no significant difference（P〉0.05）.In the PCOS group,the levels of FAI,FIN,HOMA-IR,TG,TC,and LDL-C were significantly higher in obese patients than in non-obese patients（P〈0.05）,while the levels of SHBG and HDL-C were significantly lower in obese patients than in non-obese patients（P〈0.05）.The other indexes showed no significant difference（P〈0.05）.In the control group,the levels of FIN,HOMA-IR,TG,TC,and LDL-C were significantly higher in obese patients than in non-obese patients（P〈0.05）,while the levels of SHBG and HDL-C were significantly lower in obese patients than in non-obese patients（P〈0.05）.Different from the PCOS group,there was no significant difference in FAI between obese and non-obese patients in the control group（P〈0.05）.The other indexes showed no significant difference（P〉0.05）.Conclusion The glycolipid metabolism shows abnormal features in PCOS patients and obesity is a independent factor of abnormal glycolipid metabolism.It is a matter of concern to lose weight and to prevent cardiovascular diseases.

关 键 词：多囊卵巢综合征 糖脂代谢 性激素结合球蛋白 肥胖 

分 类 号：R287[医药卫生—中药学]