新型氮杂异香豆素化合物的合成  

Synthesis of Novel 1H-pyrano[3,4-c]pyridin-1-one Derivatives

作　　者：朱岩[1] 吴健勇[1] 杨小乐[1] 陈聪慧[1] 徐峰[1] 杨珍珍[1] 吴翰桂[1] 

机构地区：[1]台州职业技术学院化学制药研究所,浙江台州318000

出　　处：《合成化学》2016年第6期494-498,共5页Chinese Journal of Synthetic Chemistry

基　　金：浙江省大学生科技创新项目(2015R462001);台州市海洋资源开发与利用创新团队子项目(HYYB201402)

摘　　要：以4-氯烟酸和芳基乙腈为原料,经取代和环合反应合成了3个新型的氮杂异香豆素化合物(3a^3c),收率32.1%~89.0%,其结构经1H NMR,IR,ESI-MS和元素分析表征。用X-单晶衍射研究了3a的亚甲基衍生物(4a)的晶体结构。4a(CCDC:935 919)属三斜晶系,空间群Pī,晶胞参数a=6.881(2),b=9.768(2),c=11.809(2),β=104.125(10)°,V=732.13,Dc=1.331 mg·cm-3,Z=2,F(000)=308,μ=0.090 mm-1。并对环合反应机理进行了研究。Three novel 1H-pyrano[3,4-c] pyridin-l-one derivatives（3a ～3c）, in yield of 32.1% - 89.0%, were synthesized by a two-step reaction of condensation and cyclization, using 4-chloronico- tinic acid and aryl acetonitrile as starting matierials. The structures were characterized by 1H NMR, IR, ESI-MS and elemental analysis. The crystal data of 4a （methylene derivative of 3a） were invest- gated by X-single crystal diffraction. 4a（ CCDC： 935 919） belongs to triclinic system, space group P i with a =6.881（2） A, b =9.768（2） A, c =11.809（2） A,β=104. 125（10）°, V=732.1 A3, Dc = 1. 331 mg· cm-3, Z = 2, F（000） = 308,μ = 0.090 mm-l The mechanism of cyclization was dis-CUSSed.

关 键 词：4-氯烟酸 芳基乙腈 氮杂异香豆素 合成 反应机理 

分 类 号：O626[理学—有机化学]