单纯疱疹病毒感染与心房颤动的相关性研究  

The relationship between herpes simplex virus infection and atrial fibrillation

作　　者：李景业[1] 刘少伟[1] 李新[1] 郭雪原[1] 张婷[1] 阮燕菲[1] 刘念[1] 杜昕[1] 董建增[1] 马长生[1] 

机构地区：[1]首都医科大学附属北京安贞医院心内科,北京100029

出　　处：《中国介入心脏病学杂志》2016年第5期261-265,共5页Chinese Journal of Interventional Cardiology

基　　金：科技部国际合作项目(2013DFB30310);北京市医院管理局临床医学发展专项经费资助(ZYLX201302);"十二五"国家科技支撑计划项目(2013BAI08B02)

摘　　要：目的观察单纯疱疹病毒(HSV)感染与心房颤动(房颤)的相关性。方法严格筛选103例孤立性房颤患者,分为阵发性房颤组74例和持续性房颤组29例,从流行病学对照研究队列中选取72例未合并房颤的健康人群作为对照组。空腹采集静脉血,用ELISA法按试剂盒标准流程检测血清HSV1 IgG抗体、HSV2 IgG抗体水平;运用相关分析探讨患者血清高敏C反应蛋白(hs-CRP)水平与HSV1 IgG抗体、HSV2 IgG抗体滴度的关系。结果对照组、阵发性房颤组和持续性房颤组的血清HSV1 IgG抗体水平分别为(217.95±53.18)μg/ml、(304.76±57.58)μg/ml和(322.99±60.35)μg/ml,血清HSV2 IgG抗体水平分别为(307.25±64.02)μg/ml、(407.22±59.1)μg/ml和(406.63±50.67)μg/ml,hs-CRP水平分别为(2.16±0.70)mg/L、(3.90±0.59)mg/L和(3.90±0.63)mg/L;对照组的血清HSV1 IgG抗体、HSV2 IgG抗体、hs-CRP水平均显著低于阵发性房颤组和持续性房颤组(均P<0.001);阵发性房颤组与持续性房颤组的血清HSV1 IgG抗体、HSV2 IgG抗体、hs-CRP水平比较,差异均无统计学意义(均P>0.05)。血清HSV IgG抗体水平与hs-CRP水平呈正相关关系(rHSV1=0.532,P<0.001;r_(HSV2)=0.446,P<0.001)。结论房颤患者的血清HSV IgG抗体水平显著升高,且与血清hs-CRP水平呈正相关。Objective To observe the correlation of herpes simplex virus（ HSV） infection and atrial fibrillation（ AF）. Methods 103 strictly selected homogenous lone AF patients were recruited,including 74 paroxysmal AF patients and 29 persistent AF patients. 72 healthy control subjects were selected from a population-based Chinese Arrhythmia Registry. Peripheral venous blood samples were collected and the concentration of IgG antibody against HSV was tested according to the standard procedure of the diagnostic ELISA kit. Results Compared to the control,AF patients were younger [（ 64. 7 ± 8. 3） years vs.（ 58. 2 ± 10. 6） years vs.（ 56. 2 ± 11. 6） years,P〈0. 001] and had a significantly higher concentration of anti-HSV1 IgG [（ 217. 95 ± 53. 18） μg / ml vs.（ 304. 76 ± 57. 58） μg / ml vs.（ 322. 99 ± 60. 35） μg/ml,P〈0. 001],anti-HSV2 IgG [（ 307. 25 ± 64. 02） μg / ml vs.（ 407. 22 ± 59. 1） μg / ml vs.（ 406. 63 ±50. 67） μg / ml,P〈0. 001] and high sensitivity C-reactive protein（ hs CRP） [（ 2. 16 ± 0. 71） mg / L vs.（ 3. 90 ± 0. 59） mg/L vs.（ 3. 90 ± 0. 63） mg/L,P〈0. 001]. There was a positive correlation between antiHSV IgG levels and hs CRP levels（ rHSV1= 0. 532,P〈0. 001; r_（HSV2）= 0. 446,P〈0. 001）.Conclusions The expression of IgG antibody against HSV was increased in AF patients,and it has a positive correlation with hs CRP levels.

关 键 词：心房颤动 单纯疱疹病毒感染 高敏C反应蛋白 

分 类 号：R541.75[医药卫生—心血管疾病]