丹红注射液对急性冠状动脉综合征患者介入治疗后内皮损伤、炎症反应程度及心功能的影响  

Effect of danhong injection on endothelial injury,degree of inflammation and cardiac function of patients with acute coronary syndrome after interventional therapy

作　　者：刘洋[1] 许金鹏[2] 邸卫英[3] 李靖[2] 徐占稳[2] 赵兴洲[2] 宋书江[2] 刘福林[4] 

机构地区：[1]保定市第二医院心外科,河北保定071051 [2]河北大学附属医院心内科,河北保定071000 [3]河北大学附属医院神经内科,河北保定071000 [4]河北大学附属医院心外科,河北保定071000

出　　处：《海南医学院学报》2016年第15期1619-1622,共4页Journal of Hainan Medical University

基　　金：河北省医学科学研究重点课题计划项目(07134)~~

摘　　要：目的：分析丹红注射液对急性冠状动脉综合征患者介入治疗后内皮损伤、炎症反应程度及心功能的影响。方法：选取2012年8月~2015年8月间在本院接受住院治疗的急性冠状动脉综合征患者104例作为研究对象,根据治疗方法不同随机分为观察组及对照组各52例。对照组患者接受常规介入治疗,观察组患者在介入治疗基础上加入丹红注射液辅助治疗,对比两组患者的内皮损伤、炎症反应程度及心功能差异。结果：观察组患者经丹红注射液辅助治疗后,血浆vWF、ET-1、NTG值低于对照组患者,NO、FMD值高于对照组患者（P〈0.05）;观察组患者的治疗后血清pentraxin-3、IL-18、IL-18/IL-10、LpPLA2值低于对照组患者,IL-10值高于对照组患者（P〈0.05）;观察组患者的治疗后LVEDV、LVESV、BNP值低于对照组患者,LVEF值高于对照组患者（P〈0.05）。结论：急性冠状动脉综合征患者在介入治疗基础上加入丹红注射液辅助治疗,可以减少血管内皮及炎症损伤,发挥积极的心功能保护作用。Objective：To analyze the effect of danhong injection on endothelial injury,degree of inflammation and car-diac function of patients with acute coronary syndrome after interventional therapy.Methods：A total of 104 patients with acute coronary syndrome who received inpatient treatment in our hospital from August 2012 to August 201 5 were chosen as the re-search subjects and randomly divided into observation group 52 cases and control group 52 cases according to different treat-ment.Control group received clinical routine interventional therapy for acute coronary syndrome,the observation group re-ceived danhong injection adjuvant treatment on the basis of interventional therapy,and then endothelial injury,the degree of in-flammation and cardiac function were compared between two groups.Results：After observation group received danhong injec-tion adjuvant treatment,plasma vWF,ET-1 and NTG value were lower than those of control group while NO and FMD value were higher than those of control group （P 〈0.05）;serum pentraxin-3,IL-18,IL-18/IL-10 and LpPLA2 value of observation group after treatment were lower than those of control group while IL-10 value was higher than that of control group （P 〈0.05）;LVEDV,LVESV and BNP value of observation group after treatment were lower than those of control group while LVEF value was higher than that of control group （P 〈0.05）.Conclusions：Danhong injection adjuvant therapy on the basis of interventional therapy for patients with acute coronary syndrome can reduce vascular endothelial and inflammatory injury,and play a positive role in cardiac protection.

关 键 词：急性冠状动脉综合征 介入治疗 丹红注射液 内皮损伤 炎症反应 心功能 

分 类 号：R541.4[医药卫生—心血管疾病]