398例服用抗血小板药物患者血栓弹力图分析  

Thrombelastograms of 398 patients treated with different antiplatelet agents

作　　者：赵旭鸿[1] 徐龙[1] 韩平[1] 华丽[1] 蔡玉婵[1] 李智[1] 

机构地区：[1]同济大学附属杨浦医院检验科,上海200090

出　　处：《检验医学》2016年第6期513-515,共3页Laboratory Medicine

摘　　要：目的分析服用抗血小板药物患者血栓弹力图(TEG)结果,为临床抗凝治疗提供参考。方法采用TEG@5000型凝血分析仪对398例服用抗血小板药物患者凝血全过程进行检测,其中≥65岁高龄患者259例,<65岁普通患者139例,分析二者检测结果的差异,总结其中38例高凝状态的3种常见情形。结果高龄患者较普通患者TEG主要数据检测水平差异有统计学意义(P<0.05)。TEG高凝状态有38例,均为高龄患者,其中酶动力型高凝状态23例(60.53%),血小板型高凝状态9例(23.68%),酶动力型和血小板型高凝状态6例(15.79%)。结论服用抗血小板药物的老年患者较普通患者高凝倾向更明显,出现高凝状态时,应正确分析原因,使用有针对性的药物,使临床抗凝治疗更安全,减少血栓的形成。Objective To analyze thrombelastograms(TEG) of patients treated with different antiplatelet agents,in order to provide a reference for clinical anticoagulation therapy. Methods The processes of coagulation were determined by TEG@5000 coagulation analyzer among 398 patients treated with different antiplatelet agents,including 259 elderly patients(≥65 years old) and 139 general patients(<65 years old). Result differences between elderly patients and general patients were analyzed. Three common types of coagulation were analyzed as well. Results The main data of TEG had statistical significance between elderly patients and general patients(P<0.05). There were 38 patients with hypercoagulability determined by TEG,and they were all elderly patients,including 23 patients with enzymatic hypercoagulability(60.53%),9 patients with platelet hypercoagulability(23.68%) and 6 patients with enzymatic and platelet hypercoagulability(15.79%). Conclusions Elderly patients above 65 years old treated with different antiplatelet agents are more likely to have hypercoagulability than other patients. It is essential to analyze the etiology of hypercoagulability in order to optimize clinical anticoagulation therapy and minimize the frequency of thrombosis.

关 键 词：血栓弹力图 高凝状态 阿司匹林 氯吡格雷 抗凝 

分 类 号：R446.1[医药卫生—诊断学]