The Effects of Ethanolamine Nitrate Ester Ferulate (ENF)on Isolated Working Guinea Pig Heart and Rat AorticRing  

阿魏硝胺对豚鼠离体工作心脏及大鼠主动脉血管环的作用

作　　者：史道华[1] 张翼[1] 郭兆贵[1] 

机构地区：[1]湖南医科大学药理研究室,解放军福州医学高等专科学校

出　　处：《Journal of Chinese Pharmaceutical Sciences》1996年第1期1-6,共6页中国药学（英文版）

摘　　要：The cardiac and vascular effect of ethanolamine nitrate ester ferulate (ENF) wasinvestigated on isolated working guinea pig heart (IWH) and rat aortic ring. The coronary blood flowwas remarkably increased while the cardiac functions of IWH were not significantly altered by ENFranging from 10-8 to 10-4 mol/L. The percentages of vasorelaxation of ENF t 10 μmol/L) and nicoran-dil (NIC, 10 μmol/L) on K+ (80 mmol/L)-induced contraction in aortic rings were 72 ± 8% and17±8%, respectively. The relaxation effects of ENF and NIC on phenylephrine (PE, 5 μmol/L) in-duced contraction were in a dose-dependent manner. When vessel segments were exposed to PE withmethylene blue (MB, 10 μmol/L) or with glibenclamide (GLI, 10 pmol/L), the percentages of relaxa-tion of ENF (10 μmol/L) and NIC ( 1 0 μmol/L) were 4 1 ±11 % and 49±7% or 76± 14% and the 33±9%,respectively. The results suggested that ENF improved coronary circulation and the vasodilation of ENF was mediated bv nitrate-like action.阿魏硝胺（ＥＮＦ）在豚鼠离体工作心脏上仅增加冠脉流量，而对心功能则无明显影响。实验同时比较了ＥＮＦ及与其有着相同活性基团的钾通道开放剂尼可地尔（ＮＩＣ）对大鼠胸主动脉血管环的舒张作用。两药对新福林（５μｍｏｌ／Ｌ）诱导的血管环收缩呈剂量依赖性舒张，其效能基本一致。格列本脲（１μｍｏｌ／Ｌ）可明显阻断ＮＩＣ（１０￣（－５）μｍｏｌ／Ｌ）的舒血管作用。但不能阻断ＥＮＦ（１０￣（－５）μ±ｍｏｌ／Ｌ）的作用。ｃＧＭＰ合成阻断剂甲蓝可使两药的舒张作用均减弱。对于８０ｍｍｏｌ／ＬＫ￣＋诱导的血管环收缩，ＥＮＦ及ＮＩＣ分别舒张７２±８％，７２±８％（Ｐ＜０．０１）。结果提示，ＥＮＦ能改善冠脉循环及通过硝基化合物样作用舒张血管而无钾通道开放作用。

关 键 词：Ethanolamine nitrate ester ferulate. Nicorandil. Cardiac function Vasodila-tion lsolated working heart 

分 类 号：R972[医药卫生—药品]