Preparation, Stability and Immunoenhancement of APS (Astragalus polysaccharide) Liposomes  

APS（黄芪多糖）脂质体的制备、稳定性和免疫促进作用

作　　者：邓英杰[1,2] 徐峰[1,2] 金义光 刘淑琴 韩丽梅[1,2] 缪硕宁[1,2] 李经才 苏德森 韩扬[1,2] 顾学裘[1,2] 

机构地区：[1]沈阳药科大学药物研究所 [2]沈阳药科大学时间药理实验室

出　　处：《Journal of Chinese Pharmaceutical Sciences》1996年第2期93-99,共7页中国药学（英文版）

摘　　要：Six factors and 10 levels of each factor were selected by using the (uniform design method( with the aid of the computer for preparing APS liposomes. The optimal procedure for preparing APS liposomes was established and it can suit the large scale production in a pharmaceutical factory. The shelf-life of APS liposomes at 20℃ is 1.46 years. Diameters of the vesicles ( > 90% ) in APS liposomes are less than 1 μm, and the system is stable. At 40℃ the diameters of vesicles were not changed in three months. Pharmacological experiments revealed that APS liposomes exerted a strong immunoenhancement in mice. Studies in this paper established a foundation for the production and the clinical application of APS liposomes.用均匀设计法设置６因素１０水平考察了ＡＰＳ脂质体制备条件，通过计算机处理结果选出适合于大规模工业化生产的最佳制备条件。ＡＰＳ脂质体２０ｏＣ贮存期为１．４６年。９０％以上的微粒直径小于１（ｍ，４０ｏＣ放置三个月，粒径仍未改变。通过检测ＡＰＳ脂质体对小鼠中性粒细胞吞噬作用，血清溶血素水平和迟发型超敏反应的影响，发现ＡＰＳ脂质体有较强的免疫促进作用。本项研究建立了ＡＰＳ脂质体生产和临床应用的基础。

关 键 词：APS liposomes STABILITY Shelf-life Immunoen 

分 类 号：R283.69[医药卫生—中药学]