左氧氟沙星联合化疗治疗复治涂阳肺结核的疗效及其对患者外周血T细胞亚群水平的影响  

Efficacy of levofloxacin combined with chemotherapy in the treatment of retreated smear positive pulmonary tuberculosis and its influence on T-cell subgroup levels in peripheral blood of patients

作　　者：杨伟荣[1] 陈伟杰[1] 凌慧琪 

机构地区：[1]广西钦州市第二人民医院感染性疾病科,广西钦州535000

出　　处：《海南医学院学报》2016年第14期1493-1495,1498,共4页Journal of Hainan Medical University

基　　金：青年科学基金项目(81302480)~~

摘　　要：目的:探讨左氧氟沙星联合化疗治疗复治涂阳肺结核(TB)的疗效及其对患者外周血T细胞亚群水平的影响。方法:将85例TB患者按照治疗方法分为对照组(n=42)与观察组(n=43),对照组采用3HRZE/6HRE的常规化疗方案进行治疗;观察组在此基础上联合左氧氟沙星进行治疗。比较两种治疗方法对患者外周血T细胞亚群水平的影响。结果:(1)观察组治疗后外周血T细胞亚群水平均显著高于对照组治疗后(P<0.05);两组治疗前后CD4^+/CD8^+水平比较,差异均无统计学意义(P>0.05);(2)对照组治疗过程中不良反应发生率为14.29%(6/42),观察组患者治疗过程中不良反应发生率为11.63%(5/43),两组患者治疗过程中不良反应发生率比较,差异无统计学意义(P>0.05)。结论:左氧氟沙星联合化疗治疗复治涂阳肺结核的疗效显著,通过改善患者外周血T细胞亚群水平而提高机体免疫功能,应在临床上进行推广。Objective:To discuss the efficacy of levofloxacin combined with chemotherapy in the treatment of retreated smear positive pulmonary tuberculosis and its influence on t-cell subgroup levels in peripheral blood of patients.Methods:85cases with TB were divided into control group(n=42)and study group(n=43)based on therapeutic methods,and patients in control group were given 3HRZE/6HRE conventional chemotherapy treatment,while patients in study group were added with levofloxacin treatment,on the basis of control group.Finally the influence of these two therapeutic methods on t-cell subgroup levels in peripheral blood of patients was compared.Results:(1)After treatment,T-cell subgroup levels in peripheral blood of patients in study group were significantly higher than that in control group(P<0.05);CD4^+/CD8^+level difference of patients in both groups had no statistical significance before and after treatment(P>0.05);(2)Adverse reaction occurrence rate of patients in control group during the therapeutic process was 14.29%(6/42),while adverse reaction occurrence rate of patients in study group during the therapeutic process was 11.63%(5/43),adverse reaction occurrence rate during the therapeutic processin both groups had no statistical significance(P>0.05).Conclusion:Efficacy of levofloxacin combined with chemotherapy in the treatment of retreated smear positive pulmonary tuberculosis was obvious,and it could improve the organism immune function through improving T-cell subgroup levels in peripheral blood of patients,which was deserved clinical popularization.

关 键 词：复治涂阳肺结核 左氧氟沙星 化疗 外周血T细胞亚群 

分 类 号：R521[医药卫生—内科学]