腺嘌呤生物金属有机框架的配位化学及超分子识别  

Adenine-based biological metal-organic frameworks:Coordination chemistry and supramolecular recognition

作　　者：才红[1,2] 许丽丽[1,2] 李冕[1] 李丹[1] 

机构地区：[1]汕头大学化学系广东省有序结构材料的制备与应用重点实验室,汕头515063 [2]韩山师范学院化学与环境工程学院,潮州521041

出　　处：《科学通报》2016年第16期1762-1773,共12页Chinese Science Bulletin

基　　金：国家自然科学基金重大研究计划重点项目(91222202);国家自然科学基金(21171114)资助;国家重点基础研究发展计划(2012CB821706;2013CB834803)

摘　　要：生物金属有机框架(biological metal-organic framework,Bio MOF)是近十来年发展起来的一类新型晶态多孔材料,它采用生物分子作为有机连接体,本身具有优良的生物相容性,为生物学和医学方面的应用提供新的机遇.本文总结了腺嘌呤作为有机配体与金属离子组装形成Bio MOF的配位化学和结构特点,介绍带有开放WatsonCrick位点(open Watson-Crick site)的Bio MOF及其主客体化学的研究,并展望其在化学和生物领域中的前景.Biological metal-organic frameworks（BioM OFs） are a new class of crystalline porous materials developed in last decade. The biomolecules introduced as the component of Bio MOFs endow biological compatibility for this type of materials,offering new opportunities of applications in the biology and medicine. In this paper,we briefly review some aspects concerning the coordination chemistry,structures and functions of BioM OFs constructed from metal and adenine,with emphasis on those equiped with the open Watson-Crick sites. Following the background introduction,the main content is divided into three sections. Section 1 summarizes examples of Bio MOFs with adenine ligand,which are categorized into two parts：（1） adenine-based MOFs constructed in the presence of auxilary ligands such as ditopic and tritopic carboxylate ligands;（2） metal-adenine-based supramolecular networks constructed through noncovalent interactions such as hydrogen bonding. The focuses are paid to the structural features of Bio MOFs with the open Watson-Crick sites and their stability and potential applications. Section 2 emphasizes on our recent progress on studying a BioM OF with the the open Watson-Crick sites,i.e. Zn BTCA,which exhibit interesting supramolecular recognition effects and nucleobase pairing. The most intriguing result is the glabal adaptive response of the host framework toward the A-T base pairing. In the last section（Section 3）,the potential host-guest chemistry and perspective in biomimicry and bioapplications of this emerging type of materials are outlined,and the possible challenges in advancing these research topics are also pointed out.

关 键 词：生物金属有机框架 腺嘌呤 开放Watson-Crick位点 主客体化学 自适应化学 

分 类 号：O641.4[理学—物理化学]