原发性高血压患者幽门螺杆菌感染及C-反应蛋白变化研究  

Research of Helicobacter pylori infection and change of C-reactive protein in patients with essential hypertension

作　　者：杨光[1] 王前胜[1] 吕云霞[1] 胡新荣[1] 刘东亮[1] 

机构地区：[1]漯河市中心医院心内科,河南漯河462000

出　　处：《中华医院感染学杂志》2016年第12期2735-2737,共3页Chinese Journal of Nosocomiology

基　　金：河南省科技厅重点基金资助项目(20130315HN)

摘　　要：目的探讨原发性高血压患者幽门螺杆菌感染与C-反应蛋白变化之间的关系,为原发性高血压的临床诊治提供参考依据。方法选取医院2012年12月-2013年10月临床收治的原发性高血压患者78例为研究组,另选取同期行健康体检人员78名为对照组,对两组受试人员的14C尿素呼气试验的阳性结果、C-反应蛋白水平进行观察和比较,数据采用SPSS 19.0统计软件进行分析。结果研究组幽门螺杆菌检出阳性率为84.62%,高于对照组的47.44%,差异有统计学意义(P<0.05);研究组幽门螺杆菌阳性患者的总胆固醇水平低于阴性患者,甘油三酯水平高于阴性患者,差异有统计学意义(P<0.05);研究组患者治疗前后C-反应蛋白水平分别为(7.43±0.81)mg/L和(2.89±0.64)mg/L,对照组为(2.67±0.54)mg/L,研究组患者治疗前C-反应蛋白水平显著高于对照组,治疗后患者的C-反应蛋白水平显著低于治疗前,差异均有统计学意(P<0.05)。结论原发性高血压患者的幽门螺杆菌感染率水平较高,患者的C-反应蛋白水平高于健康人群,对患者C-反应蛋白水平开展监测,可为临床疾病的诊治提供依据。OBJECTIVE To investigate the situation of Helicobacter pylori infection and the change of C-reactive protein in patients with essential hypertension,so as to provide related reference for the clinical diagnosis and treatment of essential hypertension.METHODS The 78 cases of hypertensive patients in the clinical treatment in our hospital from Dec.2012 to Oct.2013 were chosen as the study group.Another 78 healthy cases by health examination in our hospital during the same period were chosen as the control group.The 14 Curea breath test,Creactive protein levels for the two groups were observed and compared.Data were analyzed by statistical software SPSS 19.0.RESULTS The positive rate of H.pylori infection was 84.62%in the study group,significantly higher than 47.44%in the control group（P〈0.05）.The total cholesterol was significantly lower and the triglyceride level was significantly higher in the patients who were positive for H.pyloriinfection than the negative patients in the study group（P〈0.05）.The C-reactive protein levels in the study group before and after surgery were（7.43±0.81）mg/L and（2.89±0.64）mg/L,and the C-reactive protein level in the control group was（2.67±0.54）mg/L.The C-reactive protein level in the study group before treatment was significantly higher than the control group,the level after treatment was significantly lower than that before treatment（P〈0.05）.CONCLUSION The positive rate of H.pylori infection in patients with essential hypertension is higher,and the C-reactive protein levels were higher than the healthy people.For patients,the monitoring of C-reactive protein level can provide the basis for clinical diagnosis and treatment of disease.

关 键 词：原发性高血压 幽门螺杆菌 感染 C-反应蛋白 

分 类 号：R378[医药卫生—病原生物学]