乙型肝炎病毒与丙型肝炎病毒重叠感染患者生化免疫指标变化的临床意义  

Clinical significance of changes of biological and immune indexes in patients with HBV and HCV overlapping infection

作　　者：杨乐[1] 袁学琴[2] 蒲海波[3] 梁晓燕[1] 赵建[1] 

机构地区：[1]南阳医学高等专科学校基础医学部,河南南阳473000 [2]南阳医学高等专科学校内科教研室,河南南阳473000 [3]南阳医学高等专科学校一附院内科,河南南阳473000

出　　处：《中华医院感染学杂志》2016年第12期2738-2740,共3页Chinese Journal of Nosocomiology

基　　金：河南省科技厅重点基金资助项目(20120422FF)

摘　　要：目的探讨乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)重叠感染患者生化免疫指标变化及临床意义,为其临床研究提供参考依据。方法选择2012年1月-2015年8月65例HBV感染患者、65例HCV感染患者及70例HBV与HCV重叠感染患者作为研究对象,空腹抽取静脉血检测γ-干扰素(IFN-γ)、IFN-γ诱导蛋白10(IP-10)及肝功能指标,比较3组患者差异,数据处理采用SPSS 17.0软件进行分析。结果 HBV组患者谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBil)均高于HCV组与重叠组患者,差异有统计学意义(P<0.05);HBV组患者HBV-DNA(8.24±0.73)log10copies/ml高于重叠组患者的(5.26±0.64)log10copies/ml,差异有统计学意义(P<0.05);重叠组患者Child-Pugh评分患者IFN-γ、IP-10水平高于HBV组与HCV组患者,差异有统计学意义(P<0.05);IFN-γ及IP-10与Child-Pugh评分存在正相关关系(r=0.321、0.257,P<0.05)。结论 HBV与HCV重叠感染并未增加对肝功能的影响,但更容易引起肝组织炎性反应,降低肝脏的储备功能。OBJECTIVE To investigate the infection status caused by overlapping HBV and HCV and its influence on biochemical immune indexes so as to provide reference for the clinical research.METHODS Totally 65 patients with HBV infection,65 patients with HCV infection and 70 patients with HBV combined HCV infection were included.Venous blood was collected by fasting blood drawing to test IFN-γand IP-10 levels as well as liver function indicators.The results were compared between the three groups and data were analyzed by software SPSS17.0.RESULTS The ALT,AST,TBil levels in the HBV group were higher than in the HCV group and the overlapping group,and the difference was significant（P〈0.05）.HBV-DNA in the HBV group was（8.24±0.73）log10copies/ml,which was higher than（5.26±0.64）log10copies/ml in the overlapping group,and the difference was significant（P〈0.05）.Child-Pugh scores in the overlapping group were higher than that in the HBV group and the HCV group,and the difference was significant（P〈0.05）.The IFN-γand IP-10 levels in the overlapping group were higher than those in the HBV group and the HCV group,and the difference was significant（P〈0.05）.The IFN-γand IP-10 levels were positively correlated with Child-Pugh scores（r=0.321,0257,P〈0.05）.CONCLUSION HBV and HCV overlapping infection does not increase impact on liver function,but is more likely to cause inflammatory reaction of liver tissues and reduce the liver reserve function.

关 键 词：乙型肝炎病毒 丙型肝炎病毒 重叠感染 生化免疫指标 

分 类 号：R373.21[医药卫生—病原生物学]