侵袭性非霍奇金淋巴瘤患者化疗前CD_4^+与CD_8^+水平对化疗后感染及疗效的相关性研究  

Effects of CD_4^+ and CD_8^+ level before chemotherapy on infection after chemotherapy and efficacy in patients with aggressive non-hodgkin′s lymphoma

作　　者：徐晓燕[1] 王慧睿[1] 郭淑丽[1] 李波[1] 吕涛[1] 

机构地区：[1]洛阳市中心医院血液内科,河南洛阳471009

出　　处：《中华医院感染学杂志》2016年第12期2758-2760,共3页Chinese Journal of Nosocomiology

基　　金：河南省教育厅科学技术研究重点基金资助项目(15387323864)

摘　　要：目的探讨侵袭性非霍奇金淋巴瘤(NHL)患者化疗前CD_4^+、CD_8^+水平与化疗后感染及疗效的相关性,为临床预防NHL化疗后感染提供参考。方法选取2012年8月-2015年8月在医院住院行化疗治疗的侵袭性NHL患者100例,在患者进行化疗前1d以流式细胞仪检测T淋巴细胞亚群CD_4^+、CD_8^+水平,按照化疗方案化疗,化疗结束后31d内观察分析患者感染发生率及疗效。结果侵袭性NHL患者化疗后有34例发生感染,感染率为34.00%,感染部位以呼吸道为主,其次为皮肤黏膜,分别占58.83%、17.65%;化疗后发生感染的患者化疗前CD_4^+、CD_8^+、CD_4^+/CD_8^+水平明显低于未感染患者,比较差异有统计学意义(P<0.05);患者进行疗效评估,57例病情缓解,缓解率为57.00%;化疗后,43例病情未缓解患者CD_4^+、CD_8^+、CD_4^+/CD_8^+水平明显低于病情缓解患者,差异有统计学意义(P<0.05)。结论侵袭性NHL患者化疗前CD_4^+、CD_8^+水平对化疗后感染及疗效存在一定程度的影响,在化疗前CD_4^+、CD_8^+水平较低的患者化疗后容易发生感染及疗效不佳。OBJECTIVE To discuss the correlation of CD_4^＋and CD_8^＋level before chemotherapy and infection after chemotherapy and efficacy of patients with aggressive non-hodgkin＇s lymphoma（NHL）,so as to provide references for prevention of infection after chemotherapy in patients with NHL.METHODS A total of 100 cases of aggressive NHL patients underwent chemotherapy in hospital from Aug.2012 to Aug.2015 were selected.The T lymphocyte subsets CD_4^＋and CD_8^＋were detected using flow cytometer 1dbefore chemotherapy,The infection rate and efficacy of 31 days after chemotherapy were observed according to the chemotherapy regimens,,and the results were analyzed.RESULTS A total of 34 cases of aggressive NHL had infected after chemotherapy,with the infection rate of 34.00%.,the main infection site was the respiratory tract,followed by skin mucous membrane,accounting for 58.83% and 17.65%.The levels of CD_4^＋,CD_8^＋and CD_4^＋/CD_8^＋of infected patients after chemotherapy were significantly lower than uninfected patients（P〈0.05）.Using efficacy evaluation,57 cases had remission,accounting for 57.00%.After chemotherapy,the levels of CD_4^＋,CD_8^＋and CD_4^＋/CD_8^＋of 43 cases of non-remission patients were significantly lower than remission patients（P〈0.05）.CONCLUSION The levels of CD_4^＋and CD_8^＋before chemotherapy exist a certain degree of influence on infection after chemotherapy and efficacy in patients with aggressive NHL,and the patients with low levels of CD_4^＋and CD_8^＋before chemotherapy are easy to be infected and have poor efficacy.

关 键 词：侵袭性 非霍奇金淋巴瘤 化疗 T淋巴细胞亚群 感染 疗效 

分 类 号：R446.6[医药卫生—诊断学]