乳腺癌术后化疗患者应用脾多肽对细胞免疫功能与术后感染的影响研究  

Effect of spleen polypeptide on cellular immunity and postoperative infections in breast cancer patients undergoing postoperative chemotherapy

作　　者：李嘉[1] 许慧娟[1] 路晓庆[1] 姚景春[1] 张巍[1] 李炘正[1] 

机构地区：[1]山西省肿瘤医院乳腺二科,山西太原030013

出　　处：《中华医院感染学杂志》2016年第12期2782-2784,共3页Chinese Journal of Nosocomiology

基　　金：山西省自然科学基金资助项目(sx291823)

摘　　要：目的探讨脾多肽对乳腺癌术后化疗患者细胞免疫功能和术后感染的影响,提高患者治疗有效率和生存率,降低感染率。方法选取2011年3月-2014年3月收治的乳腺癌患者89例,随机分为观察组45例和对照组44例,对照组患者采用常规的乳腺癌术后治疗,观察组患者在对照组治疗基础上应用脾多肽;对比两组患者的细胞免疫功能以及术后感染情况,数据采用SPSS16.0软件进行统计分析。结果观察组患者术后发生感染12例,感染率26.67%,对照组患者术后发生感染23例,感染率52.27%,两组患者感染率比较,差异有统计学意义(P<0.05);观察组患者低白细胞血症Ⅰ~Ⅱ级占80.00%,明显高于对照组的40.91%,两组数据对比,差异有统计学意义(P<0.05);两组患者术后感染病原菌分布,差异无统计学意义;观察组患者的CD_4^+和CD_8^+的百分比,分别为(37.38±3.20)%和(23.00±2.96)%,CD_4^+明显表达增加,而CD_8^+的表达则少于对照组。并且自然杀伤细胞(NK)观察组为(20.94±1.82)%,也高于对照组的(17.02±4.95)%,两组数据对比差异有统计学意义(P<0.05)。结论脾多肽能够有效提高乳腺癌术后化疗患者自身免疫力,提高细胞免疫功能和减少术后感染的发生。OBJECTIVE To explore the effect of spleen polypeptide on cellular immunity and postoperative infections in breast cancer patients undergoing postoperative chemotherapy so as to raise the effective rate of treatment and survival rate and reduce the infection rate.METHODS A total of 89 breast cancer patients who were treated in the hospital from Mar 2011 to Mar 2014 were enrolled in the study and randomly divided into the observation group with 45 cases and the control group with 44 cases.The control group was treated with conventional postoperative therapy,while the observation group was given additional spleen polypeptide based on the treatment of the control group.The cellular immunity and incidence of postoperative infections were compared between the two groups of patients,and the statistical analysis of data was performed with the use of SPSS16.0software.RESULTS The incidence rate of postoperative infections was 26.67%（12cases）in the observation group,52.27%（23cases）in the control group,and there was significant difference in the infection rate between the two groups of patients（P〈0.05）.The proportion of the patients with low white blood cell viremia varying from I to II was 80.00%in the observation group,significantly higher than 40.91% in the control group（P〈0.05）.There was no significant difference in the distributuon of pathogens causing the postoperative infections between the two groups of patients.The percentages of CD_4^＋and CD_8^＋＋ of the observation group were（37.38±3.20）%and（23.00±2.96）%,respectively;the expression of CD_4^＋was remarkably increased,however,the expression of CD_8^＋of the observation group was less than that of the control group.The percentage of natural killer（NK）cell of the observation group was（20.94±1.82）%,significantly higher than（17.02 ±4.95）% of the control group（P〈0.05）.CONCLUSION Spleen polypeptide can effectively improve the immunity of the breast cancer patients undergoing the postoperative chemotherapy,boost the

关 键 词：脾多肽 乳腺癌 术后化疗 细胞免疫功能 术后感染 

分 类 号：R655.8[医药卫生—外科学]