慢性阻塞性肺疾病患者旁正中丘脑氢质子磁共振波谱分析研究  

A proton magnetic resonance spectroscopy imaging study on paramedian thalamus in patients with chronic obstructive pulmonary disease

作　　者：王存强[1] 谭西英[2] 王宇[3] 贺顺岭 顾韵泽 原子扬 

机构地区：[1]河南省新乡市第一人民医院磁共振科,河南新乡453000 [2]河南省新乡市第一人民医院神经内科,河南新乡453000 [3]河南省新乡市第一人民医院呼吸内科,河南新乡453000

出　　处：《中国现代医学杂志》2016年第11期85-88,共4页China Journal of Modern Medicine

摘　　要：目的研究慢性阻塞性肺疾病(COPD)患者旁正中丘脑氢质子磁共振波谱(1H-MRS)的特点。方法随机选取2012年2月-2015年1月在该院就诊的32例COPD患者和30例健康志愿者分别纳入研究组和对照组。采用1H-MRS检测双侧旁正中丘脑的N-乙酰基天门冬氨酸(NAA)、胆碱复合物(Cho)和肌酸复合物(Cr)。结果研究组双侧旁正中丘脑NAA/Cr值低于对照组,差异有统计学意义(P<0.05);研究组双侧旁正中丘脑Cho/Cr值高于对照组,差异有统计学意义(P<0.05)。结论 COPD患者存在旁正中丘脑神经元的代谢异常。Objective To identify the metabolite levels on paramedian thalamus in patients with COPD by proton magnetic resonance spectroscopy （^1H-MRS）. Methods Thirty-two patients with COPD in our hospital from February 2012 to January 2015 were randomly selected and 30 normal controls were also selected. ^1H- MRS was used to detect N-acetyl aspartate （NAA）, choline complex （Cho） and ereatine complex （Cr） in paramedian thalamus of all the subjects. The ratios of NAMCr and Cho/Cr were determined. Results The NAA/Cr ratio in the bilateral paramedian thalamus of the patients with COPD was significantly lower than that in the normal controls （P 〈 0.05）. The Cho/Cr ratio in the patients with COPD was higher than that in the normal controls, the difference was statistically significant （P 〈 0.05）. Conclusions Metabolisms of neurons in paramedian thalamus are abnormal in patients with COPD.

关 键 词：慢性阻塞性肺疾病 氢质子磁共振波谱分析 旁正中丘脑 

分 类 号：R563.9[医药卫生—呼吸系统] R445.2[医药卫生—内科学]