低频脉冲电联合α-硫辛酸治疗老年人2型糖尿病胃轻瘫的临床疗效  

Clinical effect of low-frequency electrical pulse therapy combined with α-lipoic acid on diabetic gastroparesis in elderly patients with type 2 diabetes

作　　者：张丹丹 罗晓燕[2] 房辉 张雅中 田金莉 

机构地区：[1]唐山市工人医院内分泌二科,063000 [2]唐山市开滦总医院急诊科,063000

出　　处：《中华老年医学杂志》2016年第6期604-607,共4页Chinese Journal of Geriatrics

摘　　要：目的 探讨低频脉冲电联合α-硫辛酸治疗老年2型糖尿病胃轻瘫患者的临床疗效。方法 选择我院老年2型糖尿病胃轻瘫患者65例，应用随机数字分组法分为3组，常规治疗组16例（常规组），α-硫辛酸治疗组23例（对照组），低频脉冲电联合α-硫辛酸治疗组26例（试验组）。所有患者均给予糖尿病常规治疗，比较3组患者治疗前后临床疗效、胃排空率、胃泌素（GAS）水平及空腹血糖水平变化。 结果 试验组患者显效率和总有效率分别为46.2%（12例）、80.8%（20例），均明显高于对照组30.4%（7例）、65.2%（15例），差异有统计学意义（均P〈0.05）；3组患者治疗前后胃排空率、GAS水平和空腹血糖水平比较差异均有统计学意义，且试验组较常规组和对照组治疗后胃排空率、GAS水平均有改善，差异有统计学意义（均P〈0.05）。结论 低频脉冲电联合α-硫辛酸治疗老年2型糖尿病胃轻瘫患者能够显著改善患者临床症状和胃动力障碍，促进胃排空，降低空腹血糖，临床疗效显著。Objective To investigate the clinical effect of low-frequency electrical pulse therapy combined with α-lipoic acid on diabetic gastroparesis in elderly patients with type 2 diabetes. Methods A total of 65 patients diagnosed as diabetic gastroparesis were selected from our hospital and divided into three groups according to random number table., the control group（n= 23, the α-lipoic acid treatment）, the conventional treatment group （n= 16）, and the experimental group （n = 26, treating with a-lipoic acid combined with low-frequency electrical pulse therapy）. All patients received the conventional diabetic therapy. Clinical effects, gastric emptying rate and serum gastrin（GAS） and fasting blood glucose levels were compared before versus after treatment among the three groups. Results The cure and total effective rates were higher in the experimental group than in the control group [46.15% （12 cases） vs. 30.43% （7 cases）, 80.76% （20 cases） vs. 65.21% （15 cases）, X2 = 0. 867, P〈0.05]. There were significant differences in gastric emptying rate, serum gastrin and fasting plasma glucose levels among the 3 treatment groups before versus after treatment. And the gastric emptying rate and serum gastrin level were better improved in the experimental groups compared with the conventional treatment and control groups. Conclusions The low-frequency electrical pulse therapy combined with α-lipoic acid has a significant clinical efficacy, which can improve clinical effects, promote gastric emptying, decrease fasting plasma glucose levels in elderly patients with type 2 diabetes.

关 键 词：糖尿病 2型 硫辛酸 脉冲疗法 药物 

分 类 号：R587.2[医药卫生—内分泌] R573[医药卫生—内科学]