四株鸭源H3N8亚型禽流感病毒对SPF鸡的感染性分析  

Infectivity of Four H3N8 Avian Influenza Viruses of Duck Origin in SPF Chickens

作　　者：崔鹏飞[1,2] 彭志[2] 张芳[2] 关立峥[1,2] 肖丽[2] 李莉莎[2] 邓国华[2] 陈化兰[1,2] 

机构地区：[1]甘肃农业大学动物医学院,兰州730070 [2]中国农业科学院哈尔滨兽医研究所农业部动物流感重点开放实验室/兽医生物技术国家重点实验室,哈尔滨150001

出　　处：《畜牧兽医学报》2016年第6期1209-1214,共6页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家自然科学基金(31572552)

摘　　要：为评价鸭源H3N8亚型禽流感病毒对鸡的感染风险,作者选取了4株HA基因位于不同进化分支的病毒进行了SPF鸡的感染性试验。结果表明,这4株H3N8亚型禽流感病毒不需要提前适应就可以感染鸡,病毒对鸡不同脏器的组织嗜性存在较大差异。鸡感染病毒后未表现出明显的临床症状,大部分感染鸡可以通过呼吸道和消化道向外排毒。此外,DK/ZJ/S4088/2013和DK/GZ/S1245/2013这两株病毒还可以由感染组的鸡传播给接触组的鸡。综上所述,本研究中的4株鸭源H3N8亚型禽流感病毒具有感染鸡并在鸡群间传播的潜在风险,在家禽的饲养和流通环节中应尽量避免鸡群与鸭群的接触。In order to evaluate the infectious risk of H3N8 avian influenza viruses（AIV）of duck origin to chickens,four H3N8 AIV viruses with HA genes belonged to different genotypes were selected to challenge SPF chickens.It was demonstrated that the four viruses could infect chickens without pre-adaptation,and the four viruses had different replication capacity in chicken＇s organs.After challenge,there weren＇t obvious clinical symptoms in chickens,and most challenged chickens could shed viruses through orpharyngeal and cloacal routes.In addition,DK/ZJ/S4088/2013 and DK/GZ/S1245/2013 could transmit from infected chickens to healthy contact chickens.In conclusion,the four duck H3N8 AIV viruses in this study posed the potential risk to infect chickens and even could transmit among chickens,and measures should be taken to avoid the contact between chickens and ducks in the breeding and circulation of poultry.

关 键 词：禽流感病毒 H3N8 鸡 感染性 

分 类 号：S852.659.5[农业科学—基础兽医学] S855.3[农业科学—兽医学]