益气化瘀方对经皮冠状动脉介入治疗急性心肌梗死术后氧化应激和炎症反应的临床观察  

Clinical Observation on the Yiqi Huayu Fang on Oxidative Stress and Inflammatory Reaction of Acute Myocardial Infarction Patients after Operation of Percutaneous Coronary Intervention

作　　者：李建功[1] 缪灿铭[1] 

机构地区：[1]广东省中山市中医院,广东中山528400

出　　处：《新中医》2016年第6期4-6,共3页New Chinese Medicine

摘　　要：目的:探讨益气化瘀方对急诊经皮冠状动脉介入治疗(PCI)急性心肌梗死(AMI)术后患者氧化应激和炎症反应的影响。方法:选取急诊PCI术后的AMI患者100例,随机分为2组各50例,2组均给予常规西医治疗,治疗组在西医基础上予口服益气化瘀方汤剂。于治疗前后测定血清过氧化物歧化酶(SOD),丙二醛(MDA)及高敏C-反应蛋白(hs-CRP)的水平。结果:总有效率治疗组为94.0%,对照组为90.0%,2组比较,差异无统计学意义(P>0.05)。显效率治疗组为74.0%,对照组为62.0%,2组比较,差异有统计学意义(P<0.05)。治疗后1、2、4周,2组MDA、SOD水平均较治疗前升高,hs-CRP水平降低,差异均有统计学意义(P<0.05);且治疗2、4周时治疗组上指标改善较对照组更显著(P<0.05)。结论:益气化瘀汤能显著提高PCI术后患者血清SOD、MDA水平,降低hs-CRP水平,临床疗效肯定。Objective：To discuss the effect of Yiqi Huayu fang on the oxidative stress and inflammatory reaction of patients of acute myocardial infarction（AMI） after percutaneous coronary intervention（PCI）. Methods：One- hundred AMI patients after PCI were chosen and divided into 2 groups with 50 cases in each group. Patients in two groups were all given the normal western medicine treatment. While the patients in the treatment group was treated orally with Yiqi Huayu fang based on the normal western medicine treatment. Measure the level of malondialdehyde（MDA）,Superoxide dismutase（SOD） and high- sensitivity C- reactive Protein（hs- CRP） in serum before and after treatment. Results：The total effective rate in the treatment group was 94.0% and that in the control group was 90.0%,the differences being not statistically significant（P〈0.05）. The effective rate was 74.0% in the treatment group and was 62.0% in the control group, the difference being significance（P〈0.05）. After one- week,two- week and four- week of treatment,the levels of MDA and SOD were all increased（P0.05 compared with before treatment）. And at the treatment of two- week and four- week,the indicators in the treatment group were improved more significantly than those in the control group（P〈0.05）. Conclusion：Yiqi Huayu fang can noticeably improve the serum levels of SOD and MDA of patient after operation and reduce the level of hs- CRP. The clinical effect is positive.

关 键 词：急性心肌梗死 经皮冠状动脉介入术 益气化瘀方 氧化应急 炎症反应 

分 类 号：R542.22[医药卫生—心血管疾病]