基于HPLC-Q-TOF/MS技术鉴定博落回叶中化学成分  

Chemical constituents in the leaves of Macleaya cordata(Willd.) R.Br identified by HPLC-Q-TOF/MS

作　　者：彭懿[1] 左姿 卿志星[1] 曾建国[1,2] 

机构地区：[1]湖南中医药大学药学院,长沙410208 [2]湖南农业大学兽用中药资源与中兽药创制国家地方联合工程研究中心,长沙410128

出　　处：《中南药学》2016年第5期465-470,共6页Central South Pharmacy

基　　金：国家科技支撑计划(No.2012BAI29B04)

摘　　要：目的快速获取博落回叶中的生物碱组分信息。方法应用HPLC-Q-TOF/MS技术鉴定博落回叶的化学成分。结果从博落回叶的甲醇提取物中鉴定了19个化合物,包括17个生物碱（3个苯并菲啶类、1个二氢苯并菲啶类、2个苄基异喹啉类、2个原小檗碱类、5个四氢原小檗碱类、3个普罗托品类和1个氮甲基-四氢原小檗碱类生物碱）、2个黄酮类化合物（1个黄酮苷和1个槲皮素）。结论化合物1~6,8首次在博落回中报道。Objective To rapidly and conveniently obtain the information for alkaloid components in the leaves ofMacleaya cordata. Methods HPLC-Q-TOF/MS was used to identify the compounds in the leaves of Ma- cleaya cordata. Results Totally 19 compounds, including 17 alkaloids （3 benzophenanthridine, 1 dihydroben- zophenanthridine, 2 benzylisoquinoline, 2 protoberberine, 5 tetrahydroprotoberberines, 3 protopines and 1 N- methyl-tetrahydroprotoberberine） and 2 flavonoids （1 flavonoid-glycoside and 1 quercetin）, were authenticated from the methanol extracts ofMacleaya cordata leaves. Conclusion Compound 1 -- 6 and 8 have been firstly reported in Macleava cordata.

关 键 词：HPLC-Q-TOF/MS 生物碱 博落回 

分 类 号：R284[医药卫生—中药学]