叶酸对心血管相关疾病作用机制及影响的研究进展  

Progress of the mechanism and impact of folic acid on cardiovascular diseases

作　　者：石仁丽 丁选胜[1] 王俐[2] 席明名[2] 黄新艳[2] 陈燕妮[2] 谢娟[2] 许银燕[2] 傅菁[2] 

机构地区：[1]中国药科大学临床药学教研室,南京210009 [2]南京医科大学附属南京市妇幼保健院,南京210004

出　　处：《中南药学》2016年第5期516-520,共5页Central South Pharmacy

摘　　要：目前叶酸主要用于各种原因引起的叶酸缺乏及其所致的巨幼红细胞贫血,妊娠期、哺乳期妇女预防给药,其中可预防胎儿先天性神经管畸形。叶酸对心血管相关疾病影响的研究结果不一。叶酸改善心血管疾病的作用机制尚不明确,其机制可能是改善氧化应激损伤、抗炎、降低同型半胱氨酸水平、增加血管内NO含量使血管扩张及改善脂质代谢紊乱等。本文对叶酸在心血管相关疾病如甲减、亚临床甲减、高血压及糖尿病中的作用机制及影响进行综述。Folic acid is mainly used for folic acid deficiency and megaloblastic anemia at present. It is used as pre- ventive drugs in pregnancy and lactation women, which can prevent fetal neural tube defects. The impact of folic acid on cardiovascular diseases is different. The mechanism of folic acid in improving cardiovascular diseases is not clear, which may be the improvment of oxidative stress damage, anti-inflammation, reducing concentration of homocysteine, increasing the level of nitricoxid to dilate blood vessels and improving lipid metabolism disorder, etc. In this article, we reviewed the mechanism and impact of folic acid on cardiovascular diseases, such as hypo- thyroidism, subclinical hypothyroidism, hypertension and diabetes.

关 键 词：叶酸 心血管疾病 甲状腺功能减退 糖尿病 高血压 

分 类 号：R54[医药卫生—心血管疾病]