肺炎支原体肺炎患儿外周血中炎性因子的变化及其意义探讨  

Changes of inflammatory factors and its significance in peripheral blood of children with myco- plasma pneumoniae pneumonia

作　　者：柯宇星[1] 赵宏霞[1] 吴春远[1] 

机构地区：[1]广东省深圳市妇幼保健院儿科二区,518000

出　　处：《中国实用医刊》2016年第12期82-84,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨肺炎支原体肺炎（MPP）患儿外周血中炎性因子的变化及其意义。方法选取2014年6月至2015年5月收治的80例MPP患儿作为观察组，同时选取同期健康体检儿童80例作为对照组。对观察组患儿急性期、恢复期及健康对照组儿童的外周静脉血C-反应蛋白（CRP）、降钙素原（PCT）、P物质（SP）、基质金属蛋白酶-9（MMP-9）含量进行检测对比。结果观察组急性期外周血CRP、PCT、SP、MMP-9含量明显高于恢复期及对照组（P〈0．01）；观察组恢复期各项外周血中炎性因子含量与对照组比较差异未见统计学意义（P〉0．05）。结论MPP患儿外周血CRP、PCT、SP、MMP-9含量与病情严重程度有明显相关性，检测其水平有助于病情判断及针对性治疗，同时对MPP发病机制的研究也有重要意义。Objective To investigate the changes of inflammatory factors and its significance in peripheral blood of children with mycoplhsma pneumoniae with MPP from June 2014 to May 2015 were selected as pneumonia（MPP）. Methods Eighty children the observation group, and selected the same number of health examination children in the same period as control group. The content of C-reactive protein （ CRP）, calcitonin （ PCT）, substance P （SP） and matrix metalloproteinase （ MMP-9 ） in the peripheral venous blood of the children in acute phase and recovery phase in the observation group and health children in the control group was compared. Results Content of CRP, PCT, SP and MMP-9 in the peripheral venous blood in the acute stage in the observation group was significantly higher than that in the recovery period and in the control group （ P 〈 0. 01 ）. Compared the recovery phase in the observation group with the control group, the content of inflammatory factors in the peripheral blood showed no significant difference（P 〉 0. 05 ）. Conclusions The content of MPP, CRP, PCT and SP in peripheral blood of children with MPP is significantly correlated with the severity of the disease, and testing its levels of the disease can help to diagnose the disease and treat it. At the same time, it also has the important significance for the study of pathogenesis of MMP.

关 键 词：肺炎支原体肺炎 C-反应蛋白 降钙素原 P物质 基质金属蛋白酶-9 

分 类 号：R725.6[医药卫生—儿科]