HIV感染者抗病毒治疗效果的非治疗影响因素分析  

Non- treatment influence factors on the antiviral treatment efficacy of HIV infection

作　　者：钟庆杨[1] 殷思纯[1] 陈桂轩[1] 何松美[1] 林沛基 张峰[2] 

机构地区：[1]东莞市人民医院感染科,广东东莞523000 [2]东莞市人民医院皮肤科,广东东莞523000

出　　处：《中国性科学》2016年第6期79-81,共3页Chinese Journal of Human Sexuality

基　　金：广东省东莞市科技计划项目(2013108101033)

摘　　要：目的:考察HIV感染者抗病毒疗效的非治疗影响因素。方法:依据治疗指南对177例HIV感染者进行抗病毒治疗,并进行流行病学调查和治疗随访。在接受抗病毒治疗前后测定患者CD4^+T淋巴细胞计数并采用多元回归模型分析影响疗效的非治疗因素。结果:治疗后患者CD4^+T淋巴细胞计数为(336.9±78.0)个/μL显著高于治疗前的(187.3±65.3)个/μL(P<0.01)。经多元回归分析,年龄、BMI指数、感染途径和治疗依从性是影响抗病毒治疗非治疗影响因素的影响因素。结论:增加治疗依从性,改善患者营养水平有助于改善HIV感染者的抗病毒疗效。Objectives： To study the non- treatment influence factors on AIDS antiviral efficacy. Methods：177 AIDS patients were treated by routine antiviral therapy,and epidemiological investigation and treatment follow-up were carried out. The CD4-＋T lymphocyte count was measured before and after treatment and multivariate regression analysis was conducted to study the non- treatment influence factors affecting the treatment efficacy. Results：After treatment,the CD4-＋T lymphocyte count was（ 336. 9 ± 78. 0） cell / μl,significantly higher than the（ 187. 3± 65. 3） cell / μl before treatment（ P〈0. 01）. In multiple regression analysis,age,BMI index,route of infection and treatment compliance were all influence factors affecting the antiviral therapy efficacy. Conclusion： Increased treatment compliance and nutrition levels in patients helps to improve the efficacy of anti- viral AIDS treatment.

关 键 词：人类免疫缺陷病毒 艾滋病 抗病毒 影响因素 

分 类 号：R512.91[医药卫生—内科学]