探究血清β-HCG及孕酮浓度在未破裂异位妊娠患者中的动态变化特点及意义  

The dynamic change characteristics and significance of β- HCG and serum progesterone concentration in patients with unruptured ectopic pregnancy

作　　者：陆婕[1] 周丽仙[1] 朱洁[1] 

机构地区：[1]嘉兴市妇幼保健院妇科,浙江嘉兴314000

出　　处：《中国性科学》2016年第6期121-123,共3页Chinese Journal of Human Sexuality

摘　　要：目的：探究与分析血清人绒毛膜促性腺激素β亚体（β-HCG）及孕酮浓度在未破裂异位妊娠患者中的动态变化特点及意义。方法：选取我院自2014年5月至2015年5月收治的60例未破裂异位妊娠患者作为试验组,选取同时期的60例正常宫内妊娠孕妇作为对照组,分别测量两组孕妇血清β-HCG与孕酮,对比48h内β-HCG的增长率及孕酮水平,比较β-HCG、孕酮及二者联合检测异位妊娠的敏感度、特异度及准确度。结果：试验组β-HCG入院时浓度、入院后浓度、浓度增长率及孕酮浓度均明显低于对照组,具有统计学意义（t=8.89,P〈0.05;t=8.67,P〈0.05;t=9.23,P〈0.05;t=10.56,P〈0.05）。联合检测与β-HCG单独检测相比敏感度、特异度、准确度均明显增高,具有统计学意义（χ-2=4.35,P〈0.05;χ-2=5.56,P〈0.05;χ-2=4.98,P〈0.05）。联合检测与孕酮单独检测相比敏感度、特异度、准确度均明显增高,具有统计学意义（χ-2=5.34,P〈0.05;χ-2=5.21,P〈0.05;χ-2=5.09,P〈0.05）。结论：异位妊娠孕妇β-HCG、孕酮浓度均明显低于正常宫内妊娠孕妇,且β-HCG与孕酮的联合检测未破裂异位妊娠具有早期、敏感、高效的特点,诊断未破裂异位妊娠方面具有重要意义,值得推广与应用。Objectives： To probe into and analyze the dynamic change characteristics and significance of β- HCG and serum progesterone concentration in patients with unruptured ectopic pregnancy. Methods： 60 patients with unruptured ectopic pregnancy in our hospital from May 2014 to May 2014 were selected as experimental group,and 60 pregnant women of normal intrauterine pregnancy were chosen as control group. The serum beta human chorionic gonadotropin（ β- HCG） and progesterone of the two groups was measured; the growth rate of β- HCG and progesterone within 48 h was compared,so as the sensitivity,specificity and accuracy of β- HCG,progesterone and the joint detection for ectopic pregnancy. Results： The concentration of β- HCG at admission,after admission and its growth rate and the progesterone concentrations was significantly lower than the control group,with statistical significance（ t = 8. 89,P〈0. 05,t = 0. 05,P〈0. 05,t = 0. 05,P〈0. 05,t = 0. 05,P〈0. 05）. Compared with β- HCG test,the sensitivity,specificity and accuracy of joint detection was significantly increased,with statistical significance（ χ-2= 4. 35,P〈0. 05; χ-2= 5. 56,P〈0. 05; χ-2= 4. 98,P〈0. 05）. Compared with progesterone detection,the sensitivity,specific and accuracy of joint detection was significantly increased,with statistical significance（ χ-2= 5. 34,P〈0. 05; χ-2= 5. 21,P〈0. 05; χ-2= 5. 09,P〈0. 05）. Conclusion： The β- HCG,progesterone concentrations of women with ectopic pregnancy is significantly lower than normal intrauterine pregnant women,and the joint detection of β- HCG and progesterone for ectopic pregnancy has the advantage of early,sensitivity and high efficiency,which is of great significance and worth popularization and application.

关 键 词：人绒毛膜促性腺激素β亚体 孕酮 异位妊娠 

分 类 号：R714.22[医药卫生—妇产科学]