内蒙古汉族寻常型银屑病REL基因多态位点检测  

Detection of the polymorphisms of REL gene in the patients with psoriasis vulgaris in Han nationality of Inner Mongolia

作　　者：王勇[1] 韩建文[2] 白云花 孙志强[2] 阿拉腾楚鲁[2] 刘佳[2] 李东霞[2] 吕新翔[2] 乌日娜[2] 

机构地区：[1]内蒙古医科大学附属医院风湿科,呼和浩特010050 [2]内蒙古医科大学附属医院皮肤科,呼和浩特010050 [3]呼伦贝尔市人民医院皮肤科,呼伦贝尔市021000

出　　处：《中国麻风皮肤病杂志》2016年第6期342-345,共4页China Journal of Leprosy and Skin Diseases

基　　金：国家自然科学基金(编号:31160192);内蒙古医科大学青年创新基金项目(编号:NY2011QN005);内蒙古自治区卫生和计划生育委员会医疗卫生科研计划项目(编号:201303057);内蒙古自治区高等学校青年科技英才支持计划(编号:NJYT-14-B17)

摘　　要：目的:检测内蒙古汉族人寻常型银屑病(PsV)患者禽网状内皮组织增殖病毒癌基因V-Rel同源基因(REL)的多态性。方法:提取301例PsV患者及292名正常对照外周血DNA,利用连接酶检测反应检测REL基因区域的4个单核苷酸多态性(SNP)(rs702873、rs 842636、rs13031237和rs13017599)。结果:PsV患者rs702873和rs 842636的等位基因频率分别为0.126和0.128,对照组中分别为0.182和0.181,差异有统计学意义(P<0.05)且rs702873和rs842636间存在强连锁不平衡(D'=0.993,r^2=0.980)。rs13031237和rs13017599等位基因频率在PsV患者和对照组中差异无统计学意义(P>0.05)。结论:REL基因位点(rs702873和rs842636)多态性可能与内蒙古汉族人PsV的易感性相关。Objective：To detect the polymorphisms of REL（v-rel avian reticuloendotheliosis viral oncogene homolog） in Han nationality of Inner Mongolia.Methods：DNA was extracted from the peripheral bloodof 301 patients and 292 healthy controls.The polymorphisms of REL gene（rs 702873,rs 842636,rs 13031237 and rs 13017599） were genotyped by PCR-based ligase detection reaction（PCR-LDR）.Results：The genotype frequencies of rs 702873 and rs 842636 in the patients were 0.126 and 0.128 and those in controls were 0.182 and 0.181,with significant difference（P〈0.05）.There was a linkage disequilibrium of rs 702873 and rs 842636.There was no significant difference in rs 13031237 and rs 13017599 between the patients and controls（P〈0.05）.Conclusion：The polymorphisms of REL gene（rs 702873 and rs 842636） are associated with psoriasis vulgaris in Han nationality of Inner Mongolia.

关 键 词：寻常型银屑病 单核苷酸多态性 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]