Synthesis and Bio-activities of Poly(3,4-ethylenedioxythiophene)(PEDOT)/Poly(styrene sulfonate)(PSS)/Gelatin Layer on Indium Tin Oxide(ITO)-coated Glass  

作　　者：随力 PENG Binbin HUANG Sijia WANG Yan JU Lihua 

机构地区：[1]School of Medical Instrument and Food Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China

出　　处：《Journal of Wuhan University of Technology(Materials Science)》2016年第3期662-670,共9页武汉理工大学学报（材料科学英文版）

基　　金：Funded by National Natural Science Foundation of China(Nos.11179015,51173108);Innovation Program of Shanghai Municipal Education Commission(No.12ZZ143)

摘　　要：Poly （3, 4-ethylenedioxythiophene） （PEDOT）, together with its dopes, such as poly （styrene sulfonate） （PSS）, has been acknowledged to have a wide range of biomedical applications as an important conducting polymer. In this study, gelatin can be polymerized into PEDOT/PSS polymers on indium tin oxide （ITO）-coated glass. PEDOT/PSS/gelatin layer on ITO-coated glass significantly decreases electrochemical impedance spectroscopy （EIS） and increases charge delivery capacity relative to the gelatin layer and bare ITO- coated glass, comparable to the PEDOT/PSS layer on ITO-coated glass. PEDOT/PSS/gelatin layer on ITO- coated glass enhances pheochromocytoma （PC 12） cell affinity, possesses a high biocompatibility and promotes PC 12 cell growth by delivery of electrical stimulation. These results suggest that gelatin can be incorporated into the PEDOT/PSS polymers through electrochemical polymerization and the PEDOT/PSS/gelatin layer on ITO-coated glass possesses high electrochemical and biological activities.Poly （3, 4-ethylenedioxythiophene） （PEDOT）, together with its dopes, such as poly （styrene sulfonate） （PSS）, has been acknowledged to have a wide range of biomedical applications as an important conducting polymer. In this study, gelatin can be polymerized into PEDOT/PSS polymers on indium tin oxide （ITO）-coated glass. PEDOT/PSS/gelatin layer on ITO-coated glass significantly decreases electrochemical impedance spectroscopy （EIS） and increases charge delivery capacity relative to the gelatin layer and bare ITO- coated glass, comparable to the PEDOT/PSS layer on ITO-coated glass. PEDOT/PSS/gelatin layer on ITO- coated glass enhances pheochromocytoma （PC 12） cell affinity, possesses a high biocompatibility and promotes PC 12 cell growth by delivery of electrical stimulation. These results suggest that gelatin can be incorporated into the PEDOT/PSS polymers through electrochemical polymerization and the PEDOT/PSS/gelatin layer on ITO-coated glass possesses high electrochemical and biological activities.

关 键 词：poly （3 4-ethylenedioxythiophene） （PEDOT） GELATIN ELECTROCHEMISTRY electrical stimulation PC 12 cell 

分 类 号：TB332[一般工业技术—材料科学与工程]