连云港农村地区高血压人群中红细胞分布宽度与血脂相关性研究  

Association of red cell distribution width with serum lipids in Lianyungang rural population with hypertension

作　　者：王力炜[1] 杨文彬[1] 於涛[1] 王雯[1] 王滨燕[2] 唐根富[1] 臧桐华[1] 秦献辉[2] 王玉[2] 李建平[3] 霍勇[3] 徐希平[1] 

机构地区：[1]安徽医科大学生物医学研究所,安徽合肥230032 [2]南方医科大学南方医院国家肾脏病临床医学研究中心,广东广州510515 [3]北京大学第一医院心内科,北京100034

出　　处：《中华疾病控制杂志》2016年第6期568-571,576,共5页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(81473052);"十二五"国家重大新药创制专项(2012ZX09101105)

摘　　要：目的 探讨连云港地区农村高血压人群中红细胞分布宽度与血脂的相关性。方法 于2008年5月～2009年7月对江苏连云港2个县的农村地区进行流行病学调查,以乡为单位,采取整群抽样筛选方法入组45～75岁的高血压人群,进行标准问卷调查、体格检查、实验室检查收集红细胞分布宽度变异系数（red blood cell distribution width-coefficient of variation,RDW-CV）,总胆固醇、甘油三酯、高密度脂蛋白,根据Friedewald公式估算低密度脂蛋白。采用多元线性回归模型评估红细胞分布宽度与血脂的相关性。结果 10906例研究对象纳入最终分析。调整性别、年龄、体质指数、收缩压、舒张压、空腹血糖、血红蛋白、平均红细胞体积、吸烟、饮酒后,RDW-CV与总胆固醇（β=-8.11,S珋x=0.55,P〈0.001）、甘油三酯（β=-3.73,S珋x=0.79,P〈0.001）、高密度脂蛋白（β=-0.96,S珋x=0.17,P〈0.001）、低密度脂蛋白（β=-6.41,S珋x=0.50,P〈0.001）呈现负相关。进一步以年龄进行分层分析中,RDW-CV与高密度脂蛋白在年龄较高组（年龄≥60versus〈60岁,交互作用P〈0.001）呈现更强的负向关联。结论 红细胞分布宽度与总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白存在相关性。Objective To examine the relationship between red cell distribution width（RDW） and serum lipids in rural hypertensives in Lianyungang. Methods An epidemiological investigation was carried out, from May 2008 to July 2009, in residents aged 45 to 75 who were enrolled randomly in a rural area of Lianyungang. Standardized questionnaire in- vestigation and physical examination were conducted lo collect information on medical history, cardiovascular risk factors, etc. Red blood cell distribution width-coefficient of variation （RDW-CV） , serum total cholesterol, triglyceride, high densi- ty lipoprotein cholesterol were measured using automatic clinical analyzers （Beckman Coulter）, and low density lipoprotein cholesterol was calculated by Friedewa｜d equation. Multiple linear regression model was performed to determine the rela- tionship between red cell distribution width and serum lipids. Results In the study, lO 906 participants with hypertension were included in the final analysis. After adjusting for sex, age, BM1, systolic blood pressure, diastolic blood pressure, fasting blood-glucose, hemoglobin, mean corpuscular volume, smoking and drinking, RDW-CV was negatively associated with total cholesterol（ β = - 8. 11, Sx=0. 55,P 〈 0. 001 ）, triglyceride （ β = - 3.73, Sx= 0. 79, P 〈 0. 001 ）, high-density lipoprotein cholesterol（ β = - 0. 96, Sx=0. 17, P 〈 0. 001 ） and low density lipoprotein eholesterol （ β -= - 6. 41, Sx= 0. 50, P 〈0. 001 ）. In the further stratified analysis, a greater association between RDW-CV and high-density l!poprotein cholesterol（ age ≥60 versus 〈 60, P for interaction 〈 0. 001 ）was observed in participants with higher age. Conclusions In conclusion, our results suggest that red cell distribution width was associated with total cholesternl, triglycefide, high- density lipoprotein cholesterol and low density lipoprotein cholesterol.

关 键 词：血脂异常 高血压 横断面研究 

分 类 号：R544.1[医药卫生—心血管疾病] R181[医药卫生—内科学]