微波辐射合成百里香酚的研究  

Synthesis of thymol with microwave irradiation

作　　者：卞云鹏 柳华锋[1] 韩莉[1] 徐铭[1] 罗金岳[1] 刘祖广 

机构地区：[1]南京林业大学化学工程学院,江苏南京210037 [2]广西林产化学与工程重点实验室,广西南宁530006

出　　处：《应用化工》2016年第6期1117-1119,1123,共4页Applied Chemical Industry

基　　金：广西林产化学与工程重点实验室重点项目(GXFC13-01)

摘　　要：以间甲酚为原料,在微波辐射下与异丙醇通过付克-烷基化反应生成了百里香酚,探讨了反应工艺条件,并采用GC-MS、IR和1H NMR等手段对产物进行了表征。结果表明,在微波辐射下,使用固体超强酸SO_4^(2-)/ZrO_2-TiO_2为催化剂,n(间甲酚)∶n(异丙醇)=1∶5,反应时间15 min,催化剂用量为原料间甲酚质量的8%,微波功率600 W,回流温度条件下百里香酚得率为59.2%。m-Cresol is used as a raw material,to synthesize thymol with isopropanol under microwave radiation by Friedel-alkylation reaction.The conditions of the reaction process were discussed.The product was characterized by GC-MS,IR and -1H NMR.The result show that under microwave radiation,the catalyst is the composite solid superacid SO_4-（2-）/ZrO_2-TiO_2.The molar proportion of m-cresol and isopropanol is 1∶5,the reaction time is 15 min,the amount of catalyst is 8%（ amount of m-cresol）,the microwave power is 600 W,under reflow temperature,the yield of thymol reaches 59.2%.

关 键 词：百里香酚 间甲酚 烷基化 微波 

分 类 号：TQ655[化学工程—精细化工] TQ651.1