Filaggrin Gene Mutation c.3321delA is Associated with Dry Phenotypes of Atopic Dermatitis in the Chinese Han Population  

作　　者：Wei-Long Zhong Xia Wu BO YU Jie Zhang Wei Zhang Ning Xu Jing Zhou Jie-Cheng Zheng Xiao-Fan Chen Xia Dou 

机构地区：[1]Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, China [2]Postgraduate School, Shantou University Medical College, Shantou, Guangdong 515041, China [3]Postgraduate School, Guangzhou Medical University, Guangzhou, Guangdong 511436, China [4]Shenzhen Key Laboratory for Translational Medicine of Dermatology, Shenzhen Peking University-The Hongkong University of Science and Technology Medical Center, Shenzhen, Guangdong 518036, China

出　　处：《Chinese Medical Journal》2016年第12期1498-1500,共3页中华医学杂志（英文版）

摘　　要：INTRODUCTION Atopic dermatitis （AD） is a common chronic inflammatory skin disorder that is characterized by dry skin and disturbed skin barrier functions. Mutations in the filaggrin （FLG） gene, the gene coding profilaggrin/filaggrin, have a great impact on the epidermal barrier function and are an important predisposing factor for AD. However, in both Europeans and Asians,INTRODUCTION Atopic dermatitis （AD） is a common chronic inflammatory skin disorder that is characterized by dry skin and disturbed skin barrier functions. Mutations in the filaggrin （FLG） gene, the gene coding profilaggrin/filaggrin, have a great impact on the epidermal barrier function and are an important predisposing factor for AD. However, in both Europeans and Asians,

关 键 词：Atopic Dermatitis c.3321 delA Mutation Filaggrin Gene Genotype-phenotype Correlation Unlabeled Probe HighResolution Melting Analysis 

分 类 号：Q347[生物学—遗传学] S826.2[农业科学—畜牧学]