抗精神病药物致心源性猝死的机制及其法医学意义  

Mechanism of antipsychotic-induced sudden cardiac death and its significance of forensic medicine

作　　者：米丽[1] 张广辉[2] 曹志鹏[3] 常月峰 朱宝利[3] 

机构地区：[1]河北北方学院基础医学院法医系,河北张家口075000 [2]天津市公安局河西分局物证鉴定所,天津300060 [3]中国医科大学法医学院,辽宁沈阳110122

出　　处：《中国法医学杂志》2016年第3期264-267,共4页Chinese Journal of Forensic Medicine

基　　金：国家自然科学基金资助项目(81273343)

摘　　要：精神障碍患者是由各种原因导致脑功能障碍并伴有一系列功能缺失和寿命缩短的群体,其死亡率为普通人群的2~5倍,且服用抗精神病药物导致猝死的发生率明显高于不服药者。大量案例报道和临床资料的回顾性研究表明,精神障碍患者发生心源性猝死风险与服用APs相关。本文简要介绍APs致心源性猝死的机制和危险因素,以期为法医学鉴定提供参考依据。Mental illness is a devastating mental disorder, which is often associated with severe loss of function and shortened life expectancy, and overall mortality in psychiatric patients is two to five fold higher than in the general population. The incidence of sudden death in patients who use the antipsychotics significantly higher than the no users. Numerous case reports and clinical retrospective studies have shown that APs have significant correlation with sudden cardiac death in mental patients.This paper reviews the mechanism of antipsychotic drugs related sudden cardiac death and its risk factors briefly, which may provide reference basis for forensic examination.

关 键 词：法医病理学 抗精神病药物 心源性猝死 

分 类 号：D919[医药卫生—法医学]