基于数据挖掘方法的当归补血汤共同分子及作用靶标研究  

Common Molecules and Function Targets for Danggui Buxue Decoction Based on Data Mining Method

作　　者：傅应军 熊旺平[1] 韦益飞 侯敏[1] 刘超[1] 余日跃[1] 黄丽萍[1] 

机构地区：[1]江西中医药大学,江西南昌330004

出　　处：《辽宁中医杂志》2016年第6期1125-1127,1,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金课题(30860350);江西省中药学高水平学科国拔经费资助课题子课题(074973)

摘　　要：目的:本研究通过数据挖掘的方法整合相关信息和计算机方法构建复杂网络模型,探索当归补血汤的药物分子及作用靶标,为当归补血汤作用机理提供依据。方法:利用数据挖掘的方法构建当归补血汤药物分子-靶标数据库,并通过计算机软件构建当归补血汤药物分子-靶标网络图;寻找当归、黄芪共同分子、共同靶标及重要靶标。结果:当归补血汤中当归含125个分子,192个靶标;黄芪含87个分子,336个靶标。其中当归、黄芪有4个共同分子和120个共同靶标。结论:本研究结果可为当归补血汤的研究提供有用的线索,促进当归补血汤作用机理的研究。Objective： To explore the drug molecules and important targets of Danggui Buxue Decoction through the data mining method and computer method to integrate information and establish acomplex network,providing the basis for Danggui Buxue Decoction Mechanism. Methods： Construct molecular- target database of Danggui Buxue Decoction by data mining method and construct drugs- target network diagram through computer software. Search the common molecules,common targets and important targets of angelica and astragalus. Results： Angelica contained 125 molecules and 192 targets. Astragalus contained 87 molecules and 336 targets. Angelica and astragalu contained 4 common molecules and 120 common targets. Conclusion： This study can provide useful clues for further research of Danggui Buxue Decoction and promote the utility of mechanism research.

关 键 词：数据挖掘 当归补血汤 药物分子 重要靶标 

分 类 号：R2-03[医药卫生—中医学]