下调的miR-21通过激活NF-κB通路促进IgA肾病的研究  

Reduced mir-21 expression contributes to Ig A nephropathy by activating NF-κB pathway

作　　者：张莹[1] 龚剑[1] 李晓蕾[1] 张冬菊[1] 

机构地区：[1]陕西省汉中市中心医院肾内科,陕西汉中723000

出　　处：《吉林医学》2016年第6期1302-1304,共3页Jilin Medical Journal

摘　　要：目的:探讨IgA肾病患者肾脏组织中miR-21的表达及其作用。方法:分别收集7例IgA肾病患者肾穿组织和6例镜下病理检查正常的肾皮质组织,应用qRT-PCR对其分析miR-21的表达。结果:miR-21在IgAN组织中的的表达明显低于正常组织。miR-21低表达可以使p65磷酸化而激活NF-κB通路。结论:miR-21低表达通过磷酸化p65激活NF-κB通路从而增强IgAN病理的炎性反应。Objective To investigate the expression and roles of the miR-21 in IgA nephropathy（ IgAN） kidney tis-sues. Method Specimens from 7 patients with IgAN were collected by biopsy,and 6 normal renal cortex specimens were collected as control group. qRT- PCR was used to detect the expression of miR-21. Results We found that miR- 21 was significantly down regulated in IgAN patients＇ renal tissues. Reduced mir- 21 expression can phosphorylate p65. Conclusion MiR- 21 can promote NF-κB signal by phosphorylating p65 which may enhance inflammation during IgAN pathogenesis.

关 键 词：微小RNA IGA肾病 P65 

分 类 号：R692.31[医药卫生—泌尿科学]