革兰氏阳性细菌铁摄取机制的研究进展  

Current research development of gram-positive bacterium iron uptake mechanisms

作　　者：蔡明辉[1] 吕春梅[1] 张晓兰[1] 朱辉[1] 

机构地区：[1]哈尔滨医科大学生理学教研室,150081

出　　处：《国际免疫学杂志》2016年第3期245-249,共5页International Journal of Immunology

基　　金：基金项目：国家自然科学基金（81571957）;哈尔滨市科学技术局科技创新人才项目（2013RFLXJ021）;黑龙江省博士后基金（LBH-Z13142）;中国博士后科学基金（2014M551267）

摘　　要：铁是大多数细菌生长存活的基本营养物质，细菌能否从宿主体内摄取足够的铁对于其毒力和致病起着关键的作用。铁在宿主体内主要以游离铁、含铁蛋白和血红素三种形式存在。细菌可以通过复杂的铁摄取机制来获得宿主体内的铁进而感染宿主。因此，探究细菌的铁摄取机制有助更好的了解细菌的生长和致病过程。Iron is the essential nutrient for the growth and survival of mnst bacterial pathogens. Bacteri- al iron uptake from host plays a key role for virulence and pathogenesis. Iron mainly exists in host in three forms： free iron,iron-containing protein and heme. Bacteria can obtain iron to infect the host by some complex i- ron uptake mechanisms. Therefore, the research on bacterial iron uptake mechanisms may help us to further un- derstand the process of bacterial growth and pathogenesis. This review provides brief information on the progress of several Gram-positive bacterium iron uptake mechanisms.

关 键 词：革兰氏阳性细菌 铁摄取 血红素 ABC转运体 

分 类 号：R378[医药卫生—病原生物学]