O型血孕妇产前血清IgG抗-A（B）抗体效价与ABO新生儿溶血病的相关性  

Relationship between the IgG antibody titer of pregnant women and the incidence of ABO hemolytic disease of newborn

作　　者：张楠 曲跃军 

机构地区：[1]平煤神马医疗集团总医院输血科,河南平顶山467099

出　　处：《中国实用医刊》2016年第11期53-55,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨孕妇IgG抗体效价与ABO新生儿溶血病（HDN）发病率的相关性。方法选择2013年1月至2015年6月产检和生育的夫妇血型不合的O型血孕妇397例，采用抗人球蛋白微柱凝胶法测定抗体效价．并对其产后进行新生儿溶血病检测，并对检测结果进行统计学分析。结果母亲IgG效价≥512者，ABO—HDN患病率为77．7％（28／36）；IgG效价为256者，ABO—HDN患病率为67．3％（31／46）；IgG效价为128者，ABO．HDN患病率为42．1％（27／64）；IgG效价为64者，ABO—HDN患病率为17．4％（15／86）。各组间新生儿溶血病发病率比较差异有统计学意义（P〈0．05），且随效价增高而增高。结论母亲孕期抗体效价与新生儿ABO溶血病的发病率与呈正相关，且随着IgG效价的增高ABO溶血病的发病率增加。应将产前血型IgG抗A（B）抗体效价检测作为常规检测项目并且定期复查有助于早期诊断HDN，指导临床干预措施，预防ABO-HDN的发生。method. The IgG antibody titer was measured in patients with type blood. Results Mother IgG titer was equal to or larger than 512, ABO hemolytic disease of newborn prevalence rate was 77.7% （28/36） ; IgG titer for 256, ABO hemolytic disease of newborn prevalence rate was 67.3% （31/46） ; IgG titer for 128, ABO hemolytic disease of newborn prevalence rate was 42. 1% （27/64） ; IgG titer was 64, ABO hemolytic disease of newborn disease rate was 17.4% （15/86）. There were significant differences in the incidence of hemolytic disease among the three groups （ P 〈 0. 05 ）, and increased with the increase of the titer. Conclusions The maternal antibody titer is positively correlated with the incidence of ABO he- molytic disease of newborn, and the incidence of ABO is increased with the increase of IgG titer. IgG A （B） antibody titer detection as a routine test item and periodic review of can help early diagnosis of HDN and guide clinical interventions to prevent the occurrence of ABO-HDN.

关 键 词：ABO血型 IGG抗体效价 新生儿溶血病 

分 类 号：R722.18[医药卫生—儿科]