青蒿琥酯抗肿瘤作用机制与临床应用的研究进展  

Review on Anti-tumor Mechanism and Clinical Application of Artesunate

作　　者：李异兴[1] 李曦雯[1] 农晓琳[1] 

机构地区：[1]广西医科大学口腔医学院口腔颌面外科,南宁530021

出　　处：《天然产物研究与开发》2016年第6期986-989,共4页Natural Product Research and Development

基　　金：国家自然科学基金(81060156);广西自然科学基金面上项目(2013GXNSFAA019231);广西卫生厅重点科研项目(重200927);广西研究生教育创新计划(201010598RY10)

摘　　要：青蒿素的可溶性衍生物青蒿琥酯(Artesunate,ART)具有潜在的抗肿瘤作用,能够抑制乳腺癌、肺癌、肝癌、胃癌、宫颈癌以及白血病等多种人类常见肿瘤。其作用机制是多方面的,包括抑制肿瘤细胞增殖和诱导肿瘤细胞分化和凋亡、调控细胞信号转导、抑制肿瘤血管新生、抑制肿瘤侵袭转移、增敏抗肿瘤化疗药物等。近年来有新的研究表明,ART亦可逆转肿瘤细胞的多药耐药作用,且抗氧化可能也是其抗肿瘤的机制之一。本文对近年来ART抗肿瘤作用机制的实验研究作了全面的归纳分析,并对ART抗肿瘤作用机制及其临床应用进行了综述。Artesunate, a water-soluble artemisinin-derivative, has been widely used as an anti-malarial agent. ART also possesses anti-tumor potential, and inhibits various common human tumors such as breast cancer, lung cancer, liver canc- er, stomach cancer, cervical cancer,leukemia, etc. The multiple mechanisms of anticancer activity of ART comprise inhi- bition of proliferation of tumor calls induction of differentiation and apoptosis, anti-angiogenesis, regulation of cell signal transduction,inhibition of invasion and metastasis. This paper presented a review of research progress on the anti-tumor mechanism and clinical application of artesunate.

关 键 词：青蒿素 青蒿琥酯 肿瘤 机制 临床 

分 类 号：R285.5[医药卫生—中药学]