祛痰化瘀汤联合西药治疗冠状动脉粥样硬化性心脏病心绞痛随机平行对照研究  

Qutan Huayu Decoction(祛痰化瘀汤) combined with Western Medicine on Coronary Heart Disease Angina, Blood Lipid and Blood Rheological Study Effects of Random and Parallel Control Study

作　　者：焦泾民 

机构地区：[1]咸阳市泾阳县泾干镇卫生院,陕西咸阳713700

出　　处：《实用中医内科杂志》2016年第6期64-67,共4页Journal of Practical Traditional Chinese Internal Medicine

摘　　要：[目的]观察祛痰化瘀汤联合西药治疗冠状动脉粥样硬化性心脏病心绞痛疗效。[方法]使用随机平行对照方法,将110例住院及门诊患者按就诊顺序编号方法简单随机分为两组。对照组55例硝酸酯类、他汀类、抗血小板制剂、β受体阻滞剂等,二联或三联用药;硝酸甘油,0.5mg/次,心绞痛发作时舌下含服;阿司匹林片,0.5g/次,3次/d;辛伐他汀,40mg/次,1次/d,晚饭后服用;低分子肝素钙,4100AXa IU+200m L生理盐水,静滴。治疗组55例祛痰化瘀汤(鹿衔草20g,延胡索、黄芪、桂枝各15g,桃仁、茯苓、半夏、香附、薤白、当归各12g,山楂、枳实、苍术、川芎、泽泻、桔梗、赤芍、黄连各10g,柴胡、红花、姜黄、牛膝各9g、甘草6g),药物浸泡30min,水煎400m L,200m L/次,早晚空腹服;西药治疗同对照组。连续治疗2周为1疗程。观测临床症状、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、全血还原黏度、全血比黏度、血浆比黏度、纤维蛋白原、红细胞压积、不良反应。连续治疗2疗程,判定疗效。[结果]血脂两组均有改善(P<0.01),治疗组优于对照组(P<0.01);全血比黏度、血浆比黏度、红细胞压积两组均有改善(P<0.01),治疗组优于对照组(P<0.05);全血还原黏度两组均有改善(P<0.01),组间无明显差异(P>0.05);纤维蛋白原两组均无显著变化(P>0.05),见表4。[结论]祛痰化瘀汤联合西药治疗冠状动脉粥样硬化性心脏病心绞痛,疗效满意,无严重不良反应,值得推广。[Objective] To observe the influence of Qutan Huayu decoction（祛痰化瘀汤） combined with western medicine on coronary heart disease angina, blood lipid and blood rheological effect. [Method] Using random parallel control method, 110 cases of inpatient and outpatient method according to the treatment sequence number is randomly divided into two groups. In the control group（55 cases） nitrate, statins, antiplatelet agents, beta blockers, and double or triple therapy; nitroglycerin, 0.5 mg, angina pectoris attacks when sublingual; aspirin and 0.5 g/time, 3 times daily; simvastatin, 40 mg/times, 1 times/d after dinner service used; low molecular weight heparin calcium, 4100 AXa IU＋200m L saline, static drops. Treatment group 55 cases of Qutan Huayu decoction（祛 痰 化 瘀 汤）（Herba Pyrolae 20 g, corydalis, Radix Astragali, cassia twig 15 g, peach kernel, Poria cocos, pinellia tuber, Rhizoma Cyperi, Allium macrostemon Bunge, angelica 12 g, hawthorn, Fructus aurantii Immaturus, Atractylodes rhizome, Rhizoma Chuanxiong, Rhizoma alismatis, Balloonflower root, red peony root, Coptis 10 g, bupleurum root, safflower, turmeric, Radix 9 g, licorice 6g）, drug soaked for 30 min, water to cook 400 m L, 200 m L/ time, sooner or later, the fasting taking; western medicine with the control group. 2 weeks of continuous treatment for 1 courses. Observation of clinical symptoms, total cholesterol（TC）, triglyceride（TG）, high density lipoprotein cholesterol（HDL-C）, low density lipoprotein cholesterol（LDL-C）, whole blood reduced viscosity, blood viscosity, plasma viscosity, fibrin fibrinogen, red cell pressure product, adverse reactions. Continuous 2 courses of treatment, the curative effect. [Results] Blood lipids in the two groups were all improved（P〈0.01）, the treatment group was better than the control group（P〈0.01）, whole blood viscosity, plasma viscosity, red blood cell pressure product of two groups were improved（P〈0.01）, treatment group was better than the controlgroup（P

关 键 词：冠状动脉粥样硬化性心脏病 心绞痛 祛痰化瘀汤 总胆固醇(TC) 甘油三酯(TG) 高密度脂蛋白胆固醇(HDL-C) 低密度脂蛋白胆固醇(LDL-C) 全血还原黏度 全血比黏度 血浆比黏度 纤维蛋白原 红细胞压积 随机平行对照研究 

分 类 号：R541.4[医药卫生—心血管疾病]