儿茶酚抑素在急性冠状动脉综合征患者中的检测价值  

Prognostic value of circulating catestatin level in patients with acute coronary syndrome

作　　者：李洁[1] 荆忱[1] 刘义欣[1] 王丽萍[1] 袁鹰[1] 王曦[2] 

机构地区：[1]空军航空医学研究所附属医院,北京100089 [2]中国人民解放军总医院

出　　处：《临床心血管病杂志》2016年第6期566-569,共4页Journal of Clinical Cardiology

摘　　要：目的:探讨儿茶酚抑素(CST)水平在急性冠状动脉综合征(ACS)患者中的检测价值。方法:将182例ACS患者分为不稳定型心绞痛(UA)组、急性ST段抬高型心肌梗死(STEMI)组、急性非ST段抬高型心肌梗死(NSTEMI)组,分别比较3组与对照组(90例)间血浆CST、去甲肾上腺素(NE)、CST/NE、Gensini评分及心率变异性(HRV)参数的差异。最后,将ACS患者分为心力衰竭(心衰)组和非心衰组,分别比较两组间血浆CST、NE、N末端脑钠肽前体(NT-proBNP)的差异。结果:ACS患者CST、NE水平值均高于对照组(P<0.05),但CST/NE与对照组及各组间比较无统计学差异(P>0.05)。3组间Gensini评分、心率、心律失常发生率,NSTEMI组、STEMI组均高于UA组(P<0.05),HRV参数,NSTEMI组、STEMI组均低于UA组(P<0.05);ACS患者伴心衰时,CST和NT-proBNP浓度均高于不伴心衰的患者(P<0.05),而NE无统计学差异(P>0.05)。结论:CST水平在ACS患者中明显升高,同时与病情轻重明显相关。Objective：To determine whether circulating level of catestatin（CST）could provide prognostic information in the development of acute coronary syndromes（ACS）.Method：The 182 ACS patients were categorized into three groups：unstable angina（UA）group,acute ST-segment elevation myocardial infarction（STEMI）group,acute non ST-segment elevation myocardial infarction（NSTEMI）group.They all were detected the blood plasma of catestatin（CST）,norepinephrine（NE）,and CST/NE ratio respectively.Then the ACS patients were categorized into two groups：heart failure group and non-heart failure group.The CST,NE and N-terminal pro-Btype natriuretic peptide（NT-proBNP）levels were detected.Result：The levels of CST and NE in ACS groups were higher than control group（P〈0.05）.But the CST/NE ratio was not statistical significance in ACS group and control group（P〉0.05）.The Gensini score,heart rate and arrhythmia rate in NSTEMI or STEMI were higher than UA subgroup（P〈0.05）,whereas the HRV in NSTIMI and STIMI were lower than UA（P〈0.05）.The levels of CST and NT-proBNP were higher in ACS with heart failure than in ACS without heart failure（P〈0.05）.Conclusion：The level of CST in ACS patients were obviously increased and were markedly correlated with the degree of disease.

关 键 词：急性冠状动脉综合征 儿茶酚抑素 去甲肾上腺素 

分 类 号：R541.4[医药卫生—心血管疾病]