他达拉非对前列腺等离子电切术后勃起功能障碍的疗效观察  

Clinical research of tadalafil for the treatment of ED after PKRP

作　　者：李磊[1,2] 高竹[2] 张国飞[1] 陈安龙[1] 吴越[1] 

机构地区：[1]新疆医科大学第六附属医院泌尿外科,新疆乌鲁木齐830002 [2]湖北省枣阳市第一人民医院泌尿外科,湖北枣阳441200

出　　处：《现代泌尿外科杂志》2016年第6期423-426,共4页Journal of Modern Urology

基　　金：新疆维吾尔自治区高技术研究发展计划项目基金(No.201110108)

摘　　要：目的评估他达拉非每日1次给药对改善经尿道四区分割法双极等离子体前列腺剜切术(FPKRP)后勃起功能障碍患者的性功能及下尿路症状的疗效及安全性。方法 58例FPKRP术后ED患者根据患者意愿分为试验组及对照组各29例,试验组每晚口服他达拉非5mg连续12周,对照组禁止服用5型磷酸二酯酶抑制剂类药物,停药后随访6个月。治疗前、后及随访6个月后分别记录两组患者国际勃起功能问卷-5(IIEF-5)评分、国际前列腺症状评分(IPSS)、生活质量评分(QOL)、最大尿流率(Qmax)及前列腺特异抗原(PSA)值,并进行比较。结果试验组ED患者中有效8例,显效17例,无效4例,总有效率86.2%(25/29)与对照组比较,差异有统计学意义(Z=-3.421,P=0.001)。试验组患者治疗后及停药6个月后随访时的总体IlEF-5评分(19.62±2.94、19.55±1.82)、IPSS评分(8.14±1.94、9.21±1.72)、QOL(1.93±0.75、2.03±0.57)及Qmax(16.34±2.34、16.35±2.15)与治疗前及对照组比较,差异均有统计学意义(P<0.05);试验组患者治疗后及停药6个月后随访时的PSA值(3.81±0.83、3.75±0.71)与治疗前及对照组比较,差异无统计学意义(P>0.05)。结论他达拉非对FPKRP术后ED患者勃起功能的恢复有较好的疗效和安全性,且可同时改善患者术后的下尿路症状,适合做为BPH术后ED患者的一线治疗方法。Objective To evaluate the efficacv and safety of tadalafil taken once daily in the treatment of ED and lower urinary tract symptoms after four area division plasmakinetic enuclea-tion of prostate.Methods 58 cases of postoperative FPKRP ED patients were assigned into expe-rimental group and control group according to their wishes,experimental group received 12 weeks of tadalafil 5mg once a day treatment,and the control group were banned on the use of PDE5 inhibitor drugs.Before and after the treatment,and after 6 months of follow-up,two groups of patients were recorded in patients with international index of erectile function index（IIEF-5）score,International Prostate Symptom Score（IPSS）,quality of life score（QOL）,maximum flow rate（Qmax）and prostate specific anti（PSA）were compared before and after the treatment.Results In the experimental group,29 cases were markedly effective in12 cases,effective in13 cases,and ineffective in4 cases,the total ef-fective rate reach86.2%,compared with the control group,the difference was statistically significant（Z=-3.421,P=0.001）.After the end of the treatment and at 6 months follow-up time,the general IIEF-5（19.62±2.94,19.55±1.82）,IPSS（8.14±1.94,9.21±1.72）、QOL（1.93±0.75,2.03±0.57）and Qmax（16.34±2.34,16.35±2.15）were significantly changed compared with before and the control group,and the difference were statistically significant（P〈0.05）;after the end of the treatment and at 6 months follow-up time,the general PSA（3.81±0.83,3.75±0.71）had no statistical significance compared with before and the control group（P〈0.05）.Conclusions Tadalafil has a better therapeutic effect and safety for the treatment of ED after FPKRP,and it can also improve LUTS symptoms,it is suitable to be recommended as a first-line therapy for patients with ED after BPH surgery.

关 键 词：他达拉非 前列腺电切 勃起功能障碍 下尿路症状 治疗效果 

分 类 号：R697.32[医药卫生—泌尿科学]