胰腺炎相关蛋白在心血管疾病中的研究进展  

Research Progress in Pancreatitis-associated Protein In Cardiovascular Disease

作　　者：王子阳[1] 张翠丽[1] 富路[1] 

机构地区：[1]哈尔滨医科大学附属第一医院心内科,哈尔滨150001

出　　处：《医学综述》2016年第12期2307-2310,共4页Medical Recapitulate

摘　　要：胰腺炎相关蛋白(PAP)是一种公认的新型抗炎症因子,与胰腺炎的发生、发展密切相关,在患有心肌梗死、心力衰竭等心血管疾病时,胰腺炎相关蛋白表达水平也会明显上调;可作为心力衰竭辅助诊断、程度分级、治疗效果评估及预后判定的新型生物学标志物。PAP不仅对心肌梗死后心肌修复具有重要作用,而且在早期识别药物性心脏毒性反应中也有重要价值。许多研究对其在心血管疾病中的抗炎症反应、抗细胞凋亡等相关作用机制进行了研究,并取得了一些新进展。Panereatitis-associated protein （PAP） is a novel cytokine with well-established anti-inflam- matory effects, which is closely related to the development of pancreatitis, and is signifieantly upregulated in the eases of myocardial infaretion, heart failure and other cardiovascular diseases. It can be used as a new hiomarker in the diagnosis, grading, treatment and prognosis assessment of heart failure. It plays an important role not only in myocardial healing after myocardial infarction,but also in the early identification of drug- induced cardiac toxicity. Many studies have been done on its mechanisms such as anti-inflammatory reaction and resistance to apoptosis in cardiovascular diseases, and some new progress has been made.

关 键 词：胰腺炎相关蛋白 心力衰竭 心肌梗死 心肌修复 

分 类 号：R541[医药卫生—心血管疾病]